The kidney can recover after acute renal injury due to its highly effective endogenous regenerative capacity. However, under certain conditions the balance between injury and repair can get disturbed. This can ultimately lead to chronic renal failure, which is an increasing problem in the clinical setting. Therapy for renal failure has greatly improved over the years, especially by the introduction of  kidney transplantation. Nevertheless, due to the shortage of donor organs and the relatively low long-term success rate after kidney transplantation, new therapeutic strategies are highly desirable. Bone marrow-derived cells (BMDC) might offer a therapeutic solution for renal failure. In this thesis we explored the differentiation choices of BMDC after acute renal injury.

Broekema, Martine,

Broekema, Martine

University of Groningen Research Database

Bone marrow-derived cells in renal repair

The kidney can recover after acute renal injury due to its highly effective endogenous regenerative capacity. However, under certain conditions the balance between injury and repair can get disturbed. This can ultimately lead to chronic renal failure, which is an increasing problem in the clinical setting. Therapy for renal failure has greatly improved over the years, especially by the introduction of kidney transplantation. Nevertheless, due to the shortage of donor organs and the relatively low long-term success rate after kidney transplantation, new therapeutic strategies are highly desirable. Bone marrow-derived cells (BMDC) might offer a therapeutic solution for renal failure. In this thesis we explored the differentiation choices of BMDC after acute renal injury

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   University of GroningenBone marrow-derived cells in renal repairBroekema, MartineIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2007Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Broekema, M. (2007). Bone marrow-derived cells in renal repair. [S.n.].CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 08-06-2022Stellingen behorende bij het proefschrift Bone Marrow-Derived Cells in Renal Repair Aangezien beenmergafkomstige cellen slechts sporadisch inbouwen in het tubulusepitheel, is het onwaarschijnlijk dat deze cellen een structurele rol spelen in tubulair herstel na schade. (dit proefschrift) 2 Beenmergafkomstige cellen zouden, door te differentieren tot interstitiele myofibroblasten, kunnen bijdragen aan het onstaan van nierfibrose. (dit proefschrift) 3 De profibrotische bijwerking van ciclosporine is niet het gevolg van toegenomen myofibroblast differentiatie van beenmergafkomstige cellen. (dit proefschrift) 4 De multipotente differentiatiecapaciteit van beenmergafkomstige cellen maakt de therapeutische toepassing van deze cellen een riskante onderneming. (dit proefschrift) 5 (W)eten is een primaire levensbehoefte van de mens. 6 Het betrekkelijk lage aantal nieuwe donoren dat naar aanleiding van BNN's "Grote Donorshow" is geregistreerd, geeft aan dat het tekort aan donoren niet het gevolg is van een tekort aan publiciteit, maar eerder te wijten valt aan de apathie van de potentiele donorpopulatie. 7 Wijziging van de huidige wet op de orgaandonatie door de invoering van het Actief Donorregistratiesysteem (ADR) is op dit moment de enige manier om het aantal orgaandonoren te verhogen. 8 De wereld is een boek en zij die niet reizen, lezen slechts een bladzijde. (H. Augustinus van Hippo) 9 Het !even is een feest, maar je moet wel zelf de slingers ophangen. 1 0 Het feit dat het dankwoord van een proefschrift op de laatste pagina staat, zorgt ervoor dat (tot en met) de laatste pagina doorgelezen wordt. Martine Broekema 14 november 2007 

Bone marrow-derived cells in renal repair

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