We hypothesise that the hypercalciuria found in the diabetic
children is due to a  renal tubular defect, caused by abnormally
elevated levels of prostaglandins or an increased sensitivity to
nornal levels of prostaglandins. ...

Zie: Summary

Damme-Lombaerts, Rita Melania Marcel Maria van,

Damme-Lombaerts, Rita Melania Marcel Maria van

University of Groningen

   University of GroningenStudies on calcium excretion in diabetic childrenDamme-Lombaerts, Rita Melania Marcel Maria vanIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:1977Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Damme-Lombaerts, R. M. M. M. V. (1977). Studies on calcium excretion in diabetic children. [S.n.].CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 12-11-2019STELLINGEN 1. Het bepalen van de 24 uurs excretie van calcium in de urine dient opgenomen te worden in het nefrologisch exploratie programma van diabetische kinderen. 2. De bruikbaarheid van de orale calcium belastings­test in de differentiaal diagnose van hyper­calciurie is vooral toe te schrijven aan de korte duur van de test. Pak et al., New Engl. J. l\1ed. 292, 497. 3. Het advies inzake insuline spuiten uitgebracht door het Nationaal Centrum voor Kruiswerk aan de apothekers en apotheekhoudende artsen in Neder­land is voor kinderen met diabetes mellitus onjuist. 4. Bij patienten met chronische proteinurie en ver­minderde nierfunctie is het aangewezen de diameter van de glomeruli te meten. 5. Pharmacologische sluiting van de ductus Botalli bij pasgeborenen verdient wel de aandacht, maar (nog) geen toepassing. 6. De veronderstelling dat akute post streptokokken glomerulonefritis een progressieve aandoening is, is onwaarschijnlijk. 7. Het nut van een groot aantal laboratoriumbepalingen bij een gezonde populatie is niet aangetoond. 8. Bij de kort segment Hirsch�rung dient naast de dilatatie ook plaats te worpen ingeruimd voor de posterior myectomie. ' 9. Bij kinderen met pseudohypoaldosteronisme wijst de bestudering vpn de zoutreabsorptie onder hypotoon zoutinfuus op een proximaal tubulair defect. 10. Ouderparticipatie in de school betekent niet dat de ouders plaats nemen in de steel van de leerkrach­ten. 11. De lofzang over huishoudelijk werk, als een eer­volle taak voor de vrouw, is een hoffelijke manier van de man om dit soort werk aan haar over te laten. Stellingen bij " Studies on urinary excretion of calcium in diabetic children", R. Van Damme-Lombaerts, 15 juni 1977 

Studies on calcium excretion in diabetic children

ARTS repository - University of Groningen

English

University of Groningen Digital Archive

NARCIS 

University of Groningen Research Database

  
 University of Groningen
Studies on calcium excretion in diabetic children
Damme-Lombaerts, Rita Melania Marcel Maria van
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
1977
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Damme-Lombaerts, R. M. M. M. V. (1977). Studies on calcium excretion in diabetic children s.n.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the
author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately
and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the
number of authors shown on this cover page is limited to 10 maximum.
Download date: 11-02-2018
SUMMARY
F o r t y - s e v e n  d i a b e t i c  c h i l d r e n  w e r e  e x a m j . n e d  s y s t e n a t i c a l l y  f o r
l - l r e  n n p q F n n e  ^ f  h w n F r e 2 l . i ' r r i A .  A n d  t h i s  w a s  d e t e C t e d  1 n  f i f t e e n  o f
t h e  c h i l d r e n .
T h i s  f i n d i n g  w a s  t h e  o r j - g 1 n  o f  a n  i n v e s t i g a t i o n  i n t o  t h e  c a l c l u m
e x c r e t i o n  o f  h e a l t h y  c h i l d r e n .  l n  t h i s  s r o u p  o f  c h i l d r e n  t h e  c a l c i u m
e x c r e t i o n  i n  t h e  u r i n e  c o r r e l a t e d  w i t h  t h e  u r i n a r y  s o d i u m  e x c r e t i o n ,
a n d  w i t h  t h e  p h o s p h a t e  i n t a k e  i n  t h e  d i e t  b u t  n o t  w i t h  t h e  c a l c l u r
i n t a k e  i n  t h e  d l e t .
Compared  w l t h  t he  con t ro l  g roup ,  i n  wh i ch  f ou r  ch i l d ren  showed
h y o e r c a l c i u r i a ,  t h e  p r o u p  o f  d i a b e t i c  c h i l d r e n  h a d  a n  a b n o r m a l l y  h i g h
i n c i d e n c e  o f  h y p e r c a l c i u r i a  ( X z  =  9 , 9 0 ;  p  <  O . 0 1 ) .  T h e  s a m e  c o n c l u s i o n
was  reached  when  t he  d i abe t i c  ch i l - d ren  we re  compared  w i l h  a  g roup  o f
t w e n t y - o n e  h e a l t h y  c h l l d r e n  w h o  r e c e i v e d  a  d l e t  w i t h  a  c a l c i u m  c o n t e n t
s i m i l a r  t o  t h a t  o f  t h e  d l a b e t i c  c h i l d r e n .
D u r i n t '  t h e  f o l l o w - u p  p e r i o d  o f  f o u r  y e a r s  f o u r  n e w  d i a b e t i c
^ . f i 6 h F e  i a r , - l ^ n 6 4  t s w ^ e n . 2 l a i t r r i a  T n  f h A  1 - n l - 2 1  o n n r r n  n f  n i n e t e e n
h w n e r e n l c i r r n j o  . h i  l . J h a h  F h a  , ' - i h - - r ,  ^ ^ l C i U n  e X C f e t i O n  W a S  . l A ^ A n 4 o n +' ' J Y  
"  "
o n  t h e  e x c r e E i o n  o f  g l u c o s e  i n  s i x  o f  t h e  c h i l , d r e n ,  b u t  w a s  i n d e p e n d e n t
o f  t h e  q l u c o s e  e x c r e t i o n  i n  t h l r t e e n  o f  t h e  c h i l d r e n .
l . ' l e t abo l -  i c  ac i dos i i s  cou ld  no t  be  shown  t o  be  t he  cause  o f  t he
h y o e r c a l c i u r i a ,  l l o  c o r r e l d t i o n  w a s  f o u n d  b e t w e e n  t h e  h y p e r c a l c i u r i a
a n d  t h e  c a l c i u r n  i n t a k e  i n  t h e  d i e t .
T h e  g r o w t h  i n  h e i g h t  o f  t h e  d i a b e t i c  c h i l d r e n  w i t h  h v p e r c a l c i u r i a
was  no t  d i , f f e ren t  f r o rn  t ha t  i n  l he  ch l l d ren  \ d i t h  a  no rma l  ca l c l um
e x c r e f i o n  i n  t h e  u r l n e .  A l I  d i a b e t i c  c h i L d r e n  h a d  a  d e c r e a s e d  c o r t i c a l
t h i c kness  o f  t he  second  rne taca rpa l  bone  when  compared  w i t h  no r rna l
v a l u e s  f r o n  t h e  l i t e r a t r l r e ,  t h e r e  w a s  h o w e v e r ,  n o  d i f f e r e n c e  b e t w e e n
t h e  h y p e r c a l c i u r i c  a n d  t h e  n o r n o c a l c i u r i c  g r o u p .
A n  o r a l  c a l c i u n  l o a d  t e s t  D r o v i d e d  e v i d e n c e  f o r  a  r e n a f  r a t h e r
L h a n  a n  i . n t e s - t i n a l  o r i g i n  o f  t h e  h y p e r c a l c l u . i a .  O r a ]  a c l m i n i s t r a t i o n
o f  i n d o m e t h a c i n  r e d u c e d  s i U n l f i c a n t l y  t h e  c a l c i u m  e x c r e t i o n ,  w i t h o u t
a l t € r i n q  t h e  s o d i u r n  e x c r e t i o n .
! / e  h y p o t h e s i s e  t h a t  t h e  h y p e r c a l c i u r i a  f o u n d  i n  t h e  d i a b e t i c
c h l l d r e n  i s  d u e  t o ; r  r e n a l  t u b u l a r  d e f e c t ,  c a u s e d  b y  a b n o r m a l l y
e l e v a t e d  l e v e I s  o l  p r o s t a f l i r n d i n s  o r  a n  i n c r e a s e d  s e n s i . t i . v i t y  t o
n o r n a l  l e v e l s  o f  p r o s t a q l a n r l i n s .
-  l o o


Studies on calcium excretion in diabetic children

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ARTS repository - University of Groningen

University of Groningen Digital Archive

NARCIS

University of Groningen Research Database