This thesis addresses the absolute risk of pregnancy related venous thromboembolism and fetal loss in women with thrombophilic defects, either single or multiple. The presented studies were performed to assess:
1 The absolute risk of venous thromboembolism during pregnancy and puerperium in women with hereditary deficiencies of antithrombin, protein C or protein S, and the contribution of other concomitant thrombophilic defects to this risk.
2 The absolute risk of fetal loss in women with hereditary deficiencies of either antithrombin, protein C or protein S, and the contribution of other concomitant thrombophilic defects to this risk.
3 The effects of thromboprophylaxis during pregnancy on fetal loss rates in women with hereditary deficiencies of either antithrombin, protein C or protein S.
4 The risk of a second fetal loss in carriers and non-carriers of either factor V Leiden or prothrombin G20210A after a first unexplained fetal loss.
5 The absolute risk of venous and arterial thromboembolism associated with high TAFI levels, and the contribution of other concomitant thrombophilic defects to this risk.
6 The absolute risk of fetal loss in women with high TAFI levels.