Basta-Jovanovic, G.

Chatterjee, P.K.

Nesic, Z.

Prostran, M.

Radojevic-Skodric, S.

Stojanovic, R.

Thiemermann, C.

Todorovic, Z.

Velickovic, R.

The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na+, respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only

University of Brighton Research Portal

Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat

Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat

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