Among the noble metals used in homogeneous catalysis, silver is the most neglected one, and only with the new millennium it has been rediscovered as suitable catalyst for a number of different organic transformations including the synthesis of heterocycles. Beside the versatility of copper catalysts and the much-in-vogue gold catalysis, silver salts and complexes demonstrated to be able to promote a number of reactions involving both sigma- and pi- activation. Its ability to act as Lewis acid as well as transition metal can be profitably used to promote domino and multicomponent transformations involving multiple bonds and heteroatoms. A certain number of examples in which silver catalysts effectively replaced copper ones or displayed an activity comparable \u2013 or higher \u2013 than more expensive gold catalysts have been reported.
Here, our recent findings on silver catalyzed domino and multicomponent reactions involving alkynes will be disclosed. In particular, this talk will be focused both on domino addition/annulation reactions of 2-alkynylacetophenone derivatives with ammonia by means of simple silver salts catalysts and on the activity of some original pyridine-containing tetra-aza macrocyclic silver complexes, called [Ag(I)(Pc-L)]), in two different transformations: the regioselective domino addition/cycloisomerization reaction of 2-alkynylbenzaldehydes with alcohols and the A3-coupling multicomponent reaction
