A receiving study was conducted to evaluate the effects of RAMP® with Rumensin® concentration (0 or 25.0 g/ton) given with one of two viral vaccinations (Titanium® 5 PH- M or Titanium® 5 plus NUPLURA® PH) on steer growth performance and morbidity. There were no significant vaccine by diet interactions observed. Neither vaccine treatment nor Rumensin® level affected intake, gain, or feed conversion. Vaccine type did not affect first pull (P = 0.19) or second pull morbidity rates (P = 0.52). These findings suggest that neither vaccine type nor Rumensin® concentration had any effect on steer growth performance or morbidity rate

Bittner, Curtis J.

Erickson, Galen E.

Hilscher, F. Henry, Hilscher

Jones, Robert M.

Stock, Rick

Wilken, Mallorie F.

English

UNL | Libraries

University of Nebraska - Lincoln
DigitalCommons@University of Nebraska - Lincoln
Nebraska Beef Cattle Reports Animal Science Department
2017
Comparison of Titanium® 5 PH- M versus
Titanium® 5 plus NUPLURA® PH with the
Presence or Absence of Monensin on Health and
Performance of Newly Received Feedlot Calves
Fed RAMP®
Robert M. Jones
University of Nebraska - Lincoln
Curtis J. Bittner
University of Nebraska-Lincoln, curtis.bittner@unl.edu
F. Henry Hilscher Hilscher
University of Nebraska-Lincoln, henry.hilscher@unl.edu
Mallorie F. Wilken
University of Nebraska-Lincoln, mfwilken@gmail.com
Rick Stock
Universitiy of Nebraska - Lincoln, rstock3@Unl.edu
This Article is brought to you for free and open access by the Animal Science Department at DigitalCommons@University of Nebraska - Lincoln. It has
been accepted for inclusion in Nebraska Beef Cattle Reports by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln.
Jones, Robert M.; Bittner, Curtis J.; Hilscher, F. Henry Hilscher; Wilken, Mallorie F.; Stock, Rick; and Erickson, Galen E.,
"Comparison of Titanium® 5 PH- M versus Titanium® 5 plus NUPLURA® PH with the Presence or Absence of Monensin on Health
and Performance of Newly Received Feedlot Calves Fed RAMP®" (2017). Nebraska Beef Cattle Reports. 934.
http://digitalcommons.unl.edu/animalscinbcr/934
See next page for additional authors
Follow this and additional works at: http://digitalcommons.unl.edu/animalscinbcr
Part of the Large or Food Animal and Equine Medicine Commons, Meat Science Commons, and
the Veterinary Preventive Medicine, Epidemiology, and Public Health Commons
Authors
Robert M. Jones, Curtis J. Bittner, F. Henry Hilscher Hilscher, Mallorie F. Wilken, Rick Stock, and Galen E.
Erickson
This article is available at DigitalCommons@University of Nebraska - Lincoln: http://digitalcommons.unl.edu/animalscinbcr/934
2017 Nebraska Beef Cattle Report · 79 
©  Th e Board Regents of the University of 
Nebraska. All rights reserved.
pens (10 pens per simple eff ect treatment) 
with 14– 21 steers per pen (equal steers/pen 
within block). During processing on d 1, all 
steers were identifi ed with an individual ear 
tag (3 tags total), individually weighed, and 
vaccinated with Somnu Shield® (Novartis 
Animal Health) administered at 2ml/steer 
and Dectomax® injectable (Zoetis Animal 
Health) administered at 1ml/110 lb of 
BW. Steer ID was utilized for treatment 
assignment to vaccine treatment based on 
odd or even numbers. All odd number ID 
tags were vaccinated with VacPH- M (2ml/
steer), while all even numbered tags were 
vaccinated with VacPH (2ml/steer).
All four treatments were fed a common 
diet consisting of 97% RAMP and 3% fi ne 
ground corn based supplement (DM Basis). 
Supplements contained either 0 or 25 g/ton 
of Rumensin® (DM basis). Both supple-
ments contained 435 g/ton of decoquinate 
(Deccox®; Zoetis Animal Health). Aft er the 
28- d receiving trial, steers were limit- fed (to 
minimize gut fi ll variation) a diet of 50% 
forage, 50% Sweet Bran (DM basis) at 2% of 
BW for 5 consecutive days before weighing 
for ending BW. Ending BW was an average 
of 2 consecutive day weights collected 
before feeding each day.
Performance data (BW, DMI, ADG, 
G:F) were analyzed using the MIXED 
procedure of SAS (SAS Inst., Inc., Cary, 
N.C.) with pen as the experimental unit. 
Th e model included Rumensin®, vaccine, 
and Rumensin® × vaccine interaction. 
Block (arrival) was included in the model 
as a fi xed eff ect. Morbidity incidence was 
evaluated as the number of fi rst treatments 
or the number of steers treated in the pen 
divided by the total number of steers in the 
pen. Additionally, the morbidity rate of two 
or more treatments was calculated as the 
number of steers treated two times divided 
by the total number of steers treated once. 
Morbidity data were analyzed with the 
GLIMMIX procedure of SAS using a bino-
mial distribution and a logit- link function.
Titanium® 5 + NUPLURA® PH (VacPH) 
(Elanco Animal Health) are both BRD 
vaccinations intended for beef cattle. Th e 
vaccine VacPH- M is labeled to deliver 
eff ective immune response against bacteria 
(Mannheimia haemolytica and Pasteurella 
multocida) and viruses (bovine viral diar-
rhea (BVD) types 1 and 2, infectious bovine 
rhinotracheitis (IBR), parainfl uenza- 3 virus 
(PI3) and bovine respiratory syncytial virus 
(BRSV)). Th e vaccine VacPH is labeled 
similarly to VacPH- M excluding protection 
against Pasteurella multocida. One common 
practice for receiving cattle today is feeding 
RAMP®, a complete starter product (Cargill 
Corn Milling) which contains a high level 
of Sweet Bran® and a minimal amount of 
forage (2013 Nebraska Beef Report, pp. 84– 
85). Th e objective of this study was to eval-
uate the eff ects of VacPH- M versus VacPH 
on steer growth performance and morbidity 
over a 28- d receiving period when steers are 
fed RAMP with or without Rumensin®.
Procedure
A feedlot receiving study was conducted 
to determine the eff ectiveness of vaccine 
at arrival on growth performance and 
health of steers over a 28- d receiving period 
when fed RAMP with 0 or 25 g/ton (DM 
basis) of Rumensin®. Th e experiment was 
conducted at the University of Nebraska- 
Lincoln Eastern Nebraska Research and 
Extension Center (ENREC) near Mead, 
NE. Crossbred steers (n = 704; initial BW = 
593 ± 49 lb) were utilized in a randomized 
block design with a 2×2 factorial treatment 
design. Upon arrival, steers were allowed 
access to water and processed within 
6 hours. Steers were weighed on d 1 to 
establish initial BW. Steers were assigned 
to one of four treatments (pen) based on 
processing order with steers assigned singly 
to treatment in sets of 4, and repeated until 
4 pens were fi lled (1 replicate). Once a pen 
replicate was fi lled, new pen replicates were 
started until all steers were assigned to 40 
Robert M. Jones
Curt J. Bittner
F. Henry Hilscher
Mallorie F. Wilken
Rick A. Stock
Galen E. Erickson
Summary with Implications
A receiving study was conducted to eval-
uate the eff ects of RAMP® with Rumensin® 
concentration (0 or 25.0 g/ton) given with 
one of two viral vaccinations (Titanium® 5 
PH- M or Titanium® 5 plus NUPLURA® PH) 
on steer growth performance and morbidity. 
Th ere were no signifi cant vaccine by diet 
interactions observed. Neither vaccine treat-
ment nor Rumensin® level aff ected intake, 
gain, or feed conversion. Vaccine type did not 
aff ect fi rst pull (P = 0.19) or second pull mor-
bidity rates (P = 0.52). Th ese fi ndings suggest 
that neither vaccine type nor Rumensin® 
concentration had any eff ect on steer growth 
performance or morbidity rate.
Introduction
Rumensin® (Elanco Animal Health) 
is an ionophore that has been shown to 
alter the rumen microbial population and 
is widely used in the feedlot industry to 
improve feed effi  ciency. However, there has 
been limited current research evaluating 
the performance and morbidity impacts of 
feeding Rumensin® during the adaptation 
or receiving period in feedlot steers. A 
common perception is that calves cannot 
be started on Rumensin® without decreasing 
intake dramatically. Th e most prevalent 
disease in the beef industry is bovine respi-
ratory disease (BRD). Respiratory disease 
can be caused by a combination of viral and 
bacterial pathogens, usually as a result of 
stress factors all interacting to cause morbid 
cattle. Titanium® 5 PH- M (VacPH- M) and 
 Comparison of Titanium® 5 PH- M versus Titanium® 5 plus 
NUPLURA® PH with the Presence or Absence of Monensin on 
Health and Performance of Newly Received 
Feedlot Calves Fed RAMP®
80 · 2017 Nebraska Beef Cattle Report
Results
No signifi cant Rumensin® × vaccine 
interactions (P > 0.27) were noted for 
growth performance or morbidity (Table 
1). Rumensin concentration did not aff ect 
DMI (P = 0.28), ADG (P = 0.94), F:G (P 
= 0.65), or ending BW (P = 0.83). While 
steers fed Rumensin® ate less feed numeri-
cally, the diff erence was small (2%) and was 
not statistically signifi cant. Th e DM off ered 
across the 28- day receiving period is shown 
in Figure 1. Th e DM off ered was consis-
tent across both treatments. Th ere was a 
tendency (P = 0.10) for steers fed 25.0 g/ton 
of Rumensin® to have a lower percentage of 
fi rst and second pulls as compared to steers 
receiving 0 g/ton of Rumensin®.
Vaccine type did not aff ect DMI (P 
= 0.52), ADG (P = 0.95), F:G (P = 0.79), 
or ending BW (P = 0.58). Th e number of 
steers pulled and treated for BRD one or 
more times was not diff erent (P = 0.19) for 
VacPH- M compared to VacPH. However, 
the numerical diff erence between vac-
cine types was similar to the numerical 
diff erence between steers fed Rumensin® or 
not. While not signifi cant, steers vaccinated 
with VacPH had numerically lower fi rst 
pulls. No diff erence (P = 0.52) was observed 
when comparing second pull rates between 
vaccine types.
Conclusion
Results suggest that neither vaccine type 
nor Rumensin® concentration had any eff ect 
on steer growth performance or morbidity 
rate for the fi rst 28- d of receiving. Including 
Rumensin® from day 1 of receiving does not 
dramatically alter DMI of newly received 
calves.
Robert M. Jones, graduate student
Curt J. Bittner, research technician
F. Henry Hilscher, research technician
Mallorie F. Wilken, Elanco Animal Health
Rick A. Stock, Cargill, Blair, NE
Galen E. Erickson, professor, Animal 
Science, Lincoln
 25
20
15
10
5
0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
Days on Feed
D
M
 o
ffe
re
d,
 lb
/d
ay
Control
Rumensin
Table 1.  Main eff ect comparisons of feeding Rumensin® and vaccine type on performance and 
morbidity over a 28- d receiving period.
Rumensin® Vaccine1
Item 0 g/
ton
25 g/
ton
P- 
value
VacPH- M VacPH P- 
value
SEM Interaction
Initial 
BW, lb
592 594 0.75 596 591 0.46 5.0 0.55
Ending 
BW, lb
680 682 0.83 683 679 0.58 6.0 0.59
DMI, lb/
day
13.7 13.4 0.28 13.6 13.4 0.52 0.2 0.94
ADG, lb 3.28 3.27 0.94 3.28 3.27 0.95 0.09 0.81
Feed:Gain2 4.14 4.08 0.65 4.13 4.09 0.79 - 0.79
Morbidity
 First pull, 
%3
22.6 17.4 0.10 22.0 17.9 0.19 2.3 0.38
 Second 
pull, %4
22.5 13.8 0.21 15.7 20.0 0.52 5.3 0.27
1 VacPH- M is Titanium 5 PH- M and VacPH is Titanium 5 +Nuplura PH.
2 Gain:Feed analyzed statistically, which is the reciprocal of Feed:Gain.
3 Percentage of steers treated one or more times as a % of total steers within the pen.
4 Percentage of steers treated two or more times, expressed as a % of steers pulled once.
Figure 1. Daily DM off ered to steers consuming a RAMP diet with or without Rumensin®.


Comparison of Titanium® 5 PH- M versus Titanium® 5 plus NUPLURA® PH with the Presence or Absence of Monensin on Health and Performance of Newly Received Feedlot Calves Fed RAMP®

DigitalCommons@University of Nebraska

University of Nebraska - LincolnDigitalCommons@University of Nebraska - LincolnNebraska Beef Cattle Reports Animal Science Department2017Comparison of Titanium® 5 PH- M versusTitanium® 5 plus NUPLURA® PH with thePresence or Absence of Monensin on Health andPerformance of Newly Received Feedlot CalvesFed RAMP®Robert M. JonesUniversity of Nebraska - LincolnCurtis J. BittnerUniversity of Nebraska-Lincoln, curtis.bittner@unl.eduF. Henry Hilscher HilscherUniversity of Nebraska-Lincoln, henry.hilscher@unl.eduMallorie F. WilkenUniversity of Nebraska-Lincoln, mfwilken@gmail.comRick StockUniversitiy of Nebraska - Lincoln, rstock3@Unl.eduThis Article is brought to you for free and open access by the Animal Science Department at DigitalCommons@University of Nebraska - Lincoln. It hasbeen accepted for inclusion in Nebraska Beef Cattle Reports by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln.Jones, Robert M.; Bittner, Curtis J.; Hilscher, F. Henry Hilscher; Wilken, Mallorie F.; Stock, Rick; and Erickson, Galen E.,"Comparison of Titanium® 5 PH- M versus Titanium® 5 plus NUPLURA® PH with the Presence or Absence of Monensin on Healthand Performance of Newly Received Feedlot Calves Fed RAMP®" (2017). Nebraska Beef Cattle Reports. 934.http://digitalcommons.unl.edu/animalscinbcr/934See next page for additional authorsFollow this and additional works at: http://digitalcommons.unl.edu/animalscinbcrPart of the Large or Food Animal and Equine Medicine Commons, Meat Science Commons, andthe Veterinary Preventive Medicine, Epidemiology, and Public Health CommonsAuthorsRobert M. Jones, Curtis J. Bittner, F. Henry Hilscher Hilscher, Mallorie F. Wilken, Rick Stock, and Galen E.EricksonThis article is available at DigitalCommons@University of Nebraska - Lincoln: http://digitalcommons.unl.edu/animalscinbcr/9342017 Nebraska Beef Cattle Report · 79 ©  Th e Board Regents of the University of Nebraska. All rights reserved.pens (10 pens per simple eff ect treatment) with 14– 21 steers per pen (equal steers/pen within block). During processing on d 1, all steers were identifi ed with an individual ear tag (3 tags total), individually weighed, and vaccinated with Somnu Shield® (Novartis Animal Health) administered at 2ml/steer and Dectomax® injectable (Zoetis Animal Health) administered at 1ml/110 lb of BW. Steer ID was utilized for treatment assignment to vaccine treatment based on odd or even numbers. All odd number ID tags were vaccinated with VacPH- M (2ml/steer), while all even numbered tags were vaccinated with VacPH (2ml/steer).All four treatments were fed a common diet consisting of 97% RAMP and 3% fi ne ground corn based supplement (DM Basis). Supplements contained either 0 or 25 g/ton of Rumensin® (DM basis). Both supple-ments contained 435 g/ton of decoquinate (Deccox®; Zoetis Animal Health). Aft er the 28- d receiving trial, steers were limit- fed (to minimize gut fi ll variation) a diet of 50% forage, 50% Sweet Bran (DM basis) at 2% of BW for 5 consecutive days before weighing for ending BW. Ending BW was an average of 2 consecutive day weights collected before feeding each day.Performance data (BW, DMI, ADG, G:F) were analyzed using the MIXED procedure of SAS (SAS Inst., Inc., Cary, N.C.) with pen as the experimental unit. Th e model included Rumensin®, vaccine, and Rumensin® × vaccine interaction. Block (arrival) was included in the model as a fi xed eff ect. Morbidity incidence was evaluated as the number of fi rst treatments or the number of steers treated in the pen divided by the total number of steers in the pen. Additionally, the morbidity rate of two or more treatments was calculated as the number of steers treated two times divided by the total number of steers treated once. Morbidity data were analyzed with the GLIMMIX procedure of SAS using a bino-mial distribution and a logit- link function.Titanium® 5 + NUPLURA® PH (VacPH) (Elanco Animal Health) are both BRD vaccinations intended for beef cattle. Th e vaccine VacPH- M is labeled to deliver eff ective immune response against bacteria (Mannheimia haemolytica and Pasteurella multocida) and viruses (bovine viral diar-rhea (BVD) types 1 and 2, infectious bovine rhinotracheitis (IBR), parainfl uenza- 3 virus (PI3) and bovine respiratory syncytial virus (BRSV)). Th e vaccine VacPH is labeled similarly to VacPH- M excluding protection against Pasteurella multocida. One common practice for receiving cattle today is feeding RAMP®, a complete starter product (Cargill Corn Milling) which contains a high level of Sweet Bran® and a minimal amount of forage (2013 Nebraska Beef Report, pp. 84– 85). Th e objective of this study was to eval-uate the eff ects of VacPH- M versus VacPH on steer growth performance and morbidity over a 28- d receiving period when steers are fed RAMP with or without Rumensin®.ProcedureA feedlot receiving study was conducted to determine the eff ectiveness of vaccine at arrival on growth performance and health of steers over a 28- d receiving period when fed RAMP with 0 or 25 g/ton (DM basis) of Rumensin®. Th e experiment was conducted at the University of Nebraska- Lincoln Eastern Nebraska Research and Extension Center (ENREC) near Mead, NE. Crossbred steers (n = 704; initial BW = 593 ± 49 lb) were utilized in a randomized block design with a 2×2 factorial treatment design. Upon arrival, steers were allowed access to water and processed within 6 hours. Steers were weighed on d 1 to establish initial BW. Steers were assigned to one of four treatments (pen) based on processing order with steers assigned singly to treatment in sets of 4, and repeated until 4 pens were fi lled (1 replicate). Once a pen replicate was fi lled, new pen replicates were started until all steers were assigned to 40 Robert M. JonesCurt J. BittnerF. Henry HilscherMallorie F. WilkenRick A. StockGalen E. EricksonSummary with ImplicationsA receiving study was conducted to eval-uate the eff ects of RAMP® with Rumensin® concentration (0 or 25.0 g/ton) given with one of two viral vaccinations (Titanium® 5 PH- M or Titanium® 5 plus NUPLURA® PH) on steer growth performance and morbidity. Th ere were no signifi cant vaccine by diet interactions observed. Neither vaccine treat-ment nor Rumensin® level aff ected intake, gain, or feed conversion. Vaccine type did not aff ect fi rst pull (P = 0.19) or second pull mor-bidity rates (P = 0.52). Th ese fi ndings suggest that neither vaccine type nor Rumensin® concentration had any eff ect on steer growth performance or morbidity rate.IntroductionRumensin® (Elanco Animal Health) is an ionophore that has been shown to alter the rumen microbial population and is widely used in the feedlot industry to improve feed effi  ciency. However, there has been limited current research evaluating the performance and morbidity impacts of feeding Rumensin® during the adaptation or receiving period in feedlot steers. A common perception is that calves cannot be started on Rumensin® without decreasing intake dramatically. Th e most prevalent disease in the beef industry is bovine respi-ratory disease (BRD). Respiratory disease can be caused by a combination of viral and bacterial pathogens, usually as a result of stress factors all interacting to cause morbid cattle. Titanium® 5 PH- M (VacPH- M) and  Comparison of Titanium® 5 PH- M versus Titanium® 5 plus NUPLURA® PH with the Presence or Absence of Monensin on Health and Performance of Newly Received Feedlot Calves Fed RAMP®80 · 2017 Nebraska Beef Cattle ReportResultsNo signifi cant Rumensin® × vaccine interactions (P > 0.27) were noted for growth performance or morbidity (Table 1). Rumensin concentration did not aff ect DMI (P = 0.28), ADG (P = 0.94), F:G (P = 0.65), or ending BW (P = 0.83). While steers fed Rumensin® ate less feed numeri-cally, the diff erence was small (2%) and was not statistically signifi cant. Th e DM off ered across the 28- day receiving period is shown in Figure 1. Th e DM off ered was consis-tent across both treatments. Th ere was a tendency (P = 0.10) for steers fed 25.0 g/ton of Rumensin® to have a lower percentage of fi rst and second pulls as compared to steers receiving 0 g/ton of Rumensin®.Vaccine type did not aff ect DMI (P = 0.52), ADG (P = 0.95), F:G (P = 0.79), or ending BW (P = 0.58). Th e number of steers pulled and treated for BRD one or more times was not diff erent (P = 0.19) for VacPH- M compared to VacPH. However, the numerical diff erence between vac-cine types was similar to the numerical diff erence between steers fed Rumensin® or not. While not signifi cant, steers vaccinated with VacPH had numerically lower fi rst pulls. No diff erence (P = 0.52) was observed when comparing second pull rates between vaccine types.ConclusionResults suggest that neither vaccine type nor Rumensin® concentration had any eff ect on steer growth performance or morbidity rate for the fi rst 28- d of receiving. Including Rumensin® from day 1 of receiving does not dramatically alter DMI of newly received calves.Robert M. Jones, graduate studentCurt J. Bittner, research technicianF. Henry Hilscher, research technicianMallorie F. Wilken, Elanco Animal HealthRick A. Stock, Cargill, Blair, NEGalen E. Erickson, professor, Animal Science, Lincoln 25201510500 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28Days on FeedDM offered, lb/dayControlRumensinTable 1.  Main eff ect comparisons of feeding Rumensin® and vaccine type on performance and morbidity over a 28- d receiving period.Rumensin® Vaccine1Item 0 g/ton25 g/tonP- valueVacPH- M VacPH P- valueSEM InteractionInitial BW, lb592 594 0.75 596 591 0.46 5.0 0.55Ending BW, lb680 682 0.83 683 679 0.58 6.0 0.59DMI, lb/day13.7 13.4 0.28 13.6 13.4 0.52 0.2 0.94ADG, lb 3.28 3.27 0.94 3.28 3.27 0.95 0.09 0.81Feed:Gain2 4.14 4.08 0.65 4.13 4.09 0.79 - 0.79Morbidity First pull, %322.6 17.4 0.10 22.0 17.9 0.19 2.3 0.38 Second pull, %422.5 13.8 0.21 15.7 20.0 0.52 5.3 0.271 VacPH- M is Titanium 5 PH- M and VacPH is Titanium 5 +Nuplura PH.2 Gain:Feed analyzed statistically, which is the reciprocal of Feed:Gain.3 Percentage of steers treated one or more times as a % of total steers within the pen.4 Percentage of steers treated two or more times, expressed as a % of steers pulled once.Figure 1. Daily DM off ered to steers consuming a RAMP diet with or without Rumensin®.

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Comparison of Titanium® 5 PH- M versus Titanium® 5 plus NUPLURA® PH with the Presence or Absence of Monensin on Health and Performance of Newly Received Feedlot Calves Fed RAMP®

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