Impact of obesity and intestinal tumor presence on the fecal metabolome of mice.

Abstract

<p>Low and high fat fed mice are compared in the first column (A,D,G). Low fat fed and genetically obese mice are compared in the second column (B,E,H). Mice with and without intestinal tumors are compared in the third column (C,F,I). The top row (A-C) shows heat maps of top 25 most significantly different metabolites for each comparison (p<0.05); color represents normalized metabolite concentration from low (blue) to high (red). The second row (D-F) shows discrimination of groups using partial least squares discriminate analysis. The third row (G-I) shows the metabolites most strongly influencing discrimination by the partial least squares discriminate analysis. The Variable Importance In Projection (VIP) score is the weighted sum of squares for the partial least-squares loadings with the amount of variance explained by each component taken into account.</p