The Hyaluronan Receptor for Endocytosis (HARE) Activates
NF-κB-mediated Gene Expression in Response to
40–400-kDa, but Not Smaller or Larger, Hyaluronans
Background: HARE mediates systemic clearance of hyaluronan (HA), which turns over continuously in tissues.
Results: HARE uptake of 40–400-kDa, but not larger or smaller, HA stimulated NF-κB activation.
Conclusion: HA-HARE signal complexes activate NF-κB and gene transcription only with optimally sized HA.
Significance: HARE responsiveness to a narrow size range ofHAdegradation products may be a sensing system to detect tissue ECM stress