Peptidomimetics based on electrospun nanofibers

Abstract

Electrospinning is a simple and versatile technique used for the fabrication of continuous micro and nanofibers. This approach is inexpensive, scalable, reliable and mainly used from polymer solutions and polymer melts. Recent studies have demonstrated that high molar mass polymers are not essential for production of uniform electrospun fibers but that sufficient intermolecular interactions acting as chain entanglements is the primary criterion. A study on the electrospinnability of short peptide chains containing natural amino acids (Gly, Ala, Leu, Val) together with a heterocyclic scaffold properly functionalized, is here reported