Antonius Budi Giri Bawono, NIM S.501202010, 2013, Heat Shock Protein 70
concentration on preterm labor. THESIS, Supervisor I: Dr. Soetrisno, dr.
SpOG(K), Supervisor II: Dr. Supriyadi Hari Respati, dr. SpOG. Program Study
of Family Medicine Magister – Biomedic Science, Post Graduate Program,
University of Sebelas Maret, Surakarta.
Background: Preterm labor rate in Indonesia was 27.9%. Heat Shock Protein 70
was considered to play a role on preterm labor due to maternal distress in low
social, economy and education women.
Objective: Analyzing that is any difference Heat Shock Protein 70 level on
preterm labor compare with normal pregnancy in Moewardi Hospital, Surakarta,
Central Java.
Methods: This was an observational research and the study design was a cross-
sectional study. Independent variable: Heat Shock Protein 70 level, dependent
variable: preterm labor. Data was analyzed by Chi square test.
Result: The number of all samples was 60 women, divided into 2 groups and
each group contained 30 women. Based on maternal characteristic on both
groups, education and nutritional status have an effect on occurrence of preterm
labor ( p = 0.008 and p = 0.002). Elementary school education women have a risk
to occur preterm labor 6.6 times greater than high school education women (PR=
6.682 and p = 0.029). In other side, middle high school women have a risk to
occur preterm labor 3 times greater than high school education women (PR =
3.27 and p = 0.054). Abnormal LILA have a risk to occur preterm labor 5.5 times
greater than normal LILA (PR = 5.5). Women with abnormal level of HSP70
have a risk to occur preterm labor 5.2 times greater than in those with normal
level (PR= 5.26 and p= 0.122).
Conclusion: There was a difference on Heat Shock Protein 70 level between
preterm labor and normal pregnancy, although there was no a statistic
significantly. LILA and education play a significant role in preterm labor.
Key word: heat shock protein 70, preterm labor, maternal distress, low
social-economic-education
Antonius Budi Giri Bawono, NIM S.501202010, 2013, Kadar Heat Shock
Protein 70 pada persalinan preterm. TESIS, Pembimbing I: Dr. Soetrisno, dr.
SpOG(K), Pembimbing II: Dr. Supriyadi Hari Respati, dr. SpOG. Program Studi
Magister Kedokteran Keluarga Minat Utama Ilmu Biomedik Universitas Sebelas
Maret Surakarta.
Latar Belakang: Angka kejadian persalinan preterm di Indonesia sebesar 27,9%.
Heat Shock Protein 70 diduga berperan dalam persalinan preterm yang
disebabkan distres maternal pada ibu berstatus sosial, ekonomi dan pendidikan
yang rendah.
Tujuan penelitian: untuk menganalisis apakah terdapat perbedaan kadar HSP70
pada persalinan preterm dibandingkan kehamilan normal di RSUD Dr.Moewardi,
Surakarta, Jawa Tengah.
Metode penelitian: Penelitian observasional analitik dan desain penelitian
potong lintang. Variabel independen: kadar Heat Shock Protein 70, variabel
dependen: persalinan preterm. Analisa statistik dengan uji Chi kuadrat.
Hasil: Jumlah subyek penelitian adalah 60 orang, terbagi ke dalam 2 kelompok
dan setiap kelompok 30 orang. Berdasarkan karakteristik ibu pada kedua
kelompok penelitian, pendidikan dan LILA berpengaruh terhadap kejadian
persalinan preterm (p = 0,008 dan p = 0,002). Ibu berpendidikan SD mengalami
persalinan preterm sebanyak 6,6 kali lebih besar (PR= 6,682 dan p = 0,029),
sedangkan berpendidikan SMP berisiko mengalami persalinan preterm sebanyak
3 kali lebih besar (PR = 3,27 dan p = 0, 054) dibanding yang berpendidikan
SMA. Ibu berLILA kurang memiliki risiko persalinan preterm sebanyak 5,5 kali
lebih besar dibanding ibu berLILA normal (PR = 5,5). Ibu berkadar HSP70 yang
tinggi (tidak normal) berisiko mengalami persalinan preterm sebanyak 5,2 kali
lebih besar dibanding kehamilan normal (PR= 5,26 dan p= 0,122).
Kesimpulan: ada perbedaan kadar Heat Shock Protein 70 pada ibu yang
mengalami persalinan preterm dibandingkan kehamilan normal, namun
didapatkan kesimpulan statistik yang tidak bermakna. LILA dan pendidikan
berpengaruh bermakna terhadap kejadian persalinan preterm.
Kata kunci: heat shock protein 70, persalinan preterm, distres maternal,
status sosial-ekonomi-pendidikan renda
