Interesting hints of a neuroendocrine\u2013immune system
cross-talk at several biological levels have been brought by many
research papers during the last decades, although no scientific
evidence has been fully established. In this study we hypothesize
that efficient neuroendocrine-immune systems interactions may be
identified at the membrane receptor level, and could be highlighted
by a structural bioinformatics research. In this paper we built a
model of the interaction between a typical gastrointestinal cancer
membrane with several substances that are supposed to be involved
in the immune response. A computational docking analysis shows
that the interaction between melatonin, as a neuroendocrine agent,
and other immune substances and mediators of the inflammatory
response may have a role in the complex relationship between
nervous and immune system
