Risposte emodinamiche durante ventilazione a pressione positiva continua a bassa frequenza con rimozione extracorporea di CO2 (LLFPPV-ECCO2R.) : studio comparativo rispetto alla ventilazione a pressione positiva continua (CPPV)

Abstract

Six lambs, where extracorporeal blood flow ranging between 600 and 1000 ml min-1 was continuously maintained, were mechanically ventilated in two different modes: continuous positive pressure ventilation (CPPV) with 5 cm H2O PEEP and low frequency positive pressure ventilation with 5 cm H2O PEEP and extracorporeal CO2 removal through a carbon dioxide membrane lung (LEPPV-ECCO2R). The blood gases were in normal ranges through both CPPV and LFPPV-ECCO2R, even if a higher PaO2 was found during CPPV. However, during LFPPV-ECCO2R, cardiac output increased about 30%, O2 transport 19.3%, while heart rate, pulmonary artery pressure and arterial pressure did not change. LFPPV-ECCO2R, in the experiments, seems to overcome some hemodynamic impairments of CPPV