Funzione renale durante ventilazione a pressione positiva continua a bassa frequenza con scambio extracorporeo di CO2.

Abstract

Six lambs anesthetized, paralyzed, tracheostomized and cystostomized were ventilated alternatively with continuous positive pressure ventilation (CPPV), at 16 breaths per min (bpm) and with LFPPV-ECCO2R, at 2 bpm. The renal function, as measured by urinary flow, creatinine clearance, osmolar clearance, and osmolar output, improved between 25% and 35%, lowering the respiratory rate from 16 to 2 bpm, at the same positive end expiratory pressure. The possible mechanism involved (antidiuretic hormone, hemodynamic factor, cardiopulmonary reflex) is discussed