Lipase-catalysed regioselective acylations in combination with regioselective glycosylations as a strategy for the synthesis of oligosaccharides: Synthesis of a series of fucosyllactose building blocks

Abstract

A family of five regioisomenc protected fucosyllactoses has been synthesised in only 14 overall steps from the easily available benzyllactoside. The adopted strategy combines enzymatic regioselective protection, introduction of ortho-gonal protecting groups and regioselective glycosylations on partially unprotected lactosidic acceptors