The main function of tumor necrosis factor alpha (TNF-a), a small polypeptide shared by all mammals, is probably protection against invading bacteria, parasites and viruses; killing of these microorganisms is facilitated in the presence of TNF-a. However, as its name suggest, TNF-a is also capable of killing tumor cells, in vitro as well as in vivo. This unique capacity has focused the attention on a possible role for this cytokine in the treatment of human cancer. ...
Zie: Samenvatting.