The aim of the research founding this thesis was to characterize the neurobiological substrate of panic disorder (PD), and to characterize the effects of treatment on the recovery of the affected neural circuitry. We tried to realize this aim by performing the studies described in this thesis, using neuroimaging (H215O PET scanning) and pharmacological challenge (pentagastrin) in PD patients and healthy control subjects.

Boshuisen, Marjolein Larissa,

Boshuisen, Marjolein Larissa

Dissertations of the University of Groningen

English

The anxious brain:neuroimaging of panic and anxiety

ARTS repository - University of Groningen

Proceedings - University of Groningen

NARCIS 

The anxious brain: neuroimaging of panic and anxiety

BOSHUISEN, MARJOLEIN LARISSA

uilis.unsyiah.ac.id

The anxious brain : neuroimaging of panic and anxiety

University of Groningen Digital Archive

University of Groningen

University of Groningen Research Database

  
 University of Groningen
The anxious brain
Boshuisen, Marjolein
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2003
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Boshuisen, M. L. (2003). The anxious brain: neuroimaging of panic and anxiety Groningen: s.n.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the
author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately
and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the
number of authors shown on this cover page is limited to 10 maximum.
Download date: 11-02-2018
THE ANXIOUS BRAIN
NEUROIMAGING OF PANIC AND ANXIETY
17355 Bosh B  22-10-2003  14:20  Pagina 1
M. L. Boshuisen, 2003 
The work described in this thesis was performed at the Department of Psychiatry of
the Groningen University Hospital, P.O. Box 30001, 9700 RB  Groningen, The
Netherlands.
All studies were approved by the Medical Ethics Committee of the Groningen
University Hospital. 
Cover illustration “The Limbic System” by Dr. Evian Gordon,
www.brainartgallery.com  
Printed by FEBODRUK B.V.
ISBN: 90-367-1951-8
17355 Bosh B  28-10-2003  15:41  Pagina 2
RIJKSUNIVERSITEIT GRONINGEN 
THE ANXIOUS BRAIN 
neuroimaging of panic and anxiety 
Proefschrift
ter verkrijging van het doctoraat in de 
Medische Wetenschappen 
aan de Rijksuniversiteit Groningen 
op gezag van de
Rector Magnificus, Dr. F. Zwarts, 
in het openbaar te verdedigen op 
maandag 24 november 2003 
om 16.00 uur 
door 
Marjolein Larissa Boshuisen 
geboren op 11 september 1969 
te Driebergen-Rijsenburg 
17355 Bosh B  22-10-2003  14:20  Pagina 3
Promotor: Prof. Dr. J.A. den Boer
Co-promotor: Dr. G.J. ter Horst
Beoordelingscommissie: Prof. Dr. R. van Dyck
Prof. Dr. J. Korf
Prof. Dr. H.M. van Praag
Prof. Dr. D. Nutt 
ISBN: 90-367-1950-x
17355 Bosh B  22-10-2003  14:20  Pagina 4
Contents
Chapter 1 Introduction 7
Chapter 2 rCBF differences between panic disorder patients and 
controls during anticipatory anxiety and rest 27
Chapter 3 Pentagastrin induced panic does not increase cerebral blood flow 
in the amygdala of panic disorder patients: a PET study 41
Chapter 4 Partial normalization of rCBF patterns after succesful 
pharmacological treatment of panic disorder patients: 
an H215O PET scan study 55
Chapter 5 Pentagastrin induced panic and spontaneous panic attacks are          
mediated by the same fear network 71
Chapter 6 Summary and concluding remarks 81
References 89
Samenvatting 103
Dankwoord 109
Curriculum Vitae 113
Publications 117
17355 Bosh B  22-10-2003  14:20  Pagina 5
voor Jurjen, Jelmer en Ilke
17355 Bosh B  22-10-2003  14:20  Pagina 6


https://pure.rug.nl/ws/files/14521523/reference.pdf

The anxious brain : neuroimaging of panic and anxiety

Abstract

Similar works

Full text

Available Versions

Dissertations of the University of Groningen

ARTS repository - University of Groningen

Proceedings - University of Groningen

Dissertations of the University of Groningen

NARCIS

uilis.unsyiah.ac.id

University of Groningen Digital Archive

University of Groningen

Proceedings - University of Groningen

University of Groningen Research Database