Dittberner, Olaf

Oehlmann, J\uf6rg

Oetken, Matthias

Schmitt, Claudia

Wagner, Martin

Abstract: The two UV screens 3-benzylidene-camphor (3-BC) and 3-(4\u2032-methylbenzylidene)-camphor (4-MBC) were tested regarding their toxicity and estrogenic activity. The Yeast Estrogen Screen (YES) and two sediment assays with the freshwater invertebrates Lumbriculus variegatus and Potamopyrgus antipodarum were performed. In the YES, both substances activated the human estrogen receptor \u3b1 with EC50 values of 44.2 \u3bcM for 3-BC and 44.3 \u3bcM for 4-MBC, whereby 4-MBC attained only 8% of the maximal response of 17\u3b2-estradiol. For P. antipodarum embryo production increased after exposure to both substances (EC50 of 4.60 \u3bcM 4-MBC = 1.17 mg kg 121 dw) while mortality increased at high concentrations. The reproduction of L. variegatus was decreased by 3-BC with an EC50 of 5.95 \u3bcM (=1.43 mg kg 121 dw) and also by 4-MBC, where no EC50 could be calculated. While reproduction decreased, the worms' weight increased after exposure to 3-BC with an EC50 of 26.9 \u3bcM (= 6.46 mg kg 121 dw), hence the total biomass remained unaffected. UV screens can have a significant impact on reproduction and development of aquatic invertebrates

Institutional Repository Universiteit Antwerpen

Endocrine modulation and toxic effects of two commonly used UV screens on the aquatic invertebrates **Potamopyrgus antipodarum** and **Lumbriculus variegatus**

Endocrine modulation and toxic effects of two commonly used UV screens on the aquatic invertebrates Potamopyrgus antipodarum and Lumbriculus variegatus

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Institutional Repository Universiteit Antwerpen