A new
variant of the Wilcox molecular torsion balance featuring a naphthyl-alkyl
side arm was synthesized. The energy barrier for axial isomerization
in the new balance was sufficiently high to allow for separation of
the two rotamers and to observe their isomerization kinetics. The
CH−π interaction energies in derivatives of the new and
the original ester balance were in close agreement, suggesting that
the motion in ester linkage is not an important factor in folding
in the ester balance