Miokardo deformavimosi rodiklių įvertinimas širdies magnetinio rezonanso tyrimu bandomuosiuose ir klinikiniuose tyrimuose

Abstract

The aim and objectives of the study. The aim of the study. The aim of our study is to assess advantages and reproducibility of myocardial deformation parameters derived using cardiovascular magnetic resonance feature tracking technique in experimental animal (mouse) model and patients with acute and previous myocardial infarction. The objectives of the study. 1. To assess inter- and intra-observer agreement of CMR feature tracking derived strain measurements in mice and define sudy sample size necessary for future trials. 2. To assess changes in myocardial tissue after myocardial infarction using advanced CMR imaging (nDixon) and investigate changes in global and regional myocardial deformation in patients with old myocardial infarction and lipomatous metaplasia. 3. To evaluate left atrial performance during acute ischemia and mitral regurgitation. Also, to assess inter- and intra-observer variability of CMR feature tracking derived left atrial strain and strain rate measurements