Background: White Soybean (Glycine max) Milk Ultra High Temperature (UHT) is
potential to protect gaster because it contains flavonoid. This study aimed to
investigate the protective effect of white soybean milk UHT on mice’s gaster due to
aspirin. Higher dose of the milk reduces the damaged on gastric mucous induced by
aspirin
Methods: This was a labroratory experimental research with posttest only controlled
group design conducted in in Histology Laboratory of Sebelas Maret University. The
samples were thirty five mice divided into 5 groups. Negative control group (KN)
was given normal food and aquadest, positive control group (KP) was given aspirin
dose 2,275 mg/20g Body weight (W), dan first treatment group (P1) was given
cimetidine dose 0,78 mg/20g W second treatment group (P2) and third treatment
group (P3) was given soybean milk UHT dose 0,7ml/20 g W and 1,4 ml/20 g W. All
treatments for KN, KP, P1 , P2, P3 was given in 10 days. Aspirin was given to KP, P1
, P2, P3 with dose 2,275 mg/20g weight of mice on day 8, 9 and 10. to evaluate
the level of damage based on histologic appearance, gastric staining was
performed using Haem eos.
Results: Kruskal-Wallis test result showed significant result among four groups.
Mann-Whitney showed significant result for KN compared to KP,P1,P2 , P3 and KP
compared to P1, P2 and P3 ; while P1 compared to P2, P3 and P2 compared to P3
had no significant result.
Conclusion: White Soybean (Glycine max) Milk Ultra High Temperature(UHT) protect
mice’s gastric from gastritis. However, higher dose of White Soybean (Glycine max)
Milk Ultra High Temperature(UHT) does not increase the protective effect of white
soybean milk UHT on mice’s gaster due to aspirin
