Langlois, Xavier

Schmidt, Mark

Staelens, Steven

Stroobants, Sigrid

Van Der Linden, Anne-Marie

Verhaeghe, Jeroen

Waldron, Ann-Marie

Wyffels, Leonie

Abstract: Purpose The aim of this study was to compare [11C]Pittsburgh compound B ([11C]PiB) and [18F]florbetaben ([18F]FBB) for preclinical investigations of amyloid-\u3b2 pathology. Procedures We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-\u3b2 relating to high (APPPS1-21 n\u2009=\u20096, wild type (WT) n\u2009=\u20097) and low (BRI1-42 n\u2009=\u20096, WT n\u2009=\u20096) target states, respectively. Results APPPS1-21 mice (high target state) demonstrated extensive fibrillar amyloid-\u3b2 deposition that translated to significantly increased retention of [11C]PiB and [18F]FBB in comparison to their wild type. The retention pattern of [11C]PiB and [18F]FBB in this cohort displayed a significant correlation. However, the relative difference in tracer uptake between diseased and healthy mice was substantially higher for [11C]PiB than for [18F]FBB. Although immunohistochemistry confirmed the high plaque load in APPPS1-21 mice, correlation between tracer uptake and ex vivo quantification of amyloid-\u3b2 was poor for both tracers. BRI1-42 mice (low target state) did not demonstrate increased tracer uptake. Conclusions In cases of high fibrillar amyloid-\u3b2 burden, both tracers detected significant differences between diseased and healthy mice, with [11C]PiB showing a larger dynamic range

Institutional Repository Universiteit Antwerpen

Preclinical comparison of the amyloid-<tex>\beta$</tex> radioligands [<tex>^{11}C$</tex>]Pittsburgh compound B and [<tex>^{18}F$</tex>]florbetaben in aged APPPS1-21 and BRI1-42 mouse models of cerebral amyloidosis

Preclinical comparison of the amyloid-<tex>\beta $</tex> radioligands [<tex>^{11}C$ </tex>]Pittsburgh compound B and [<tex>^{18}F$</tex>]florbetaben in aged APPPS1-21 and BRI1-42 mouse models of cerebral amyloidosis

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Institutional Repository Universiteit Antwerpen

Preclinical comparison of the amyloid-<tex>\beta</tex>radioligands[<tex>11C</tex> radioligands [<tex>^{11}C</tex>radioligands[<tex>11C</tex>]Pittsburgh compound B and [<tex>^{18}F$</tex>]florbetaben in aged APPPS1-21 and BRI1-42 mouse models of cerebral amyloidosis

Abstract

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Full text

Available Versions

Institutional Repository Universiteit Antwerpen

Preclinical comparison of the amyloid-<tex>\beta $</tex> radioligands [<tex>^{11}C$ </tex>]Pittsburgh compound B and [<tex>^{18}F$</tex>]florbetaben in aged APPPS1-21 and BRI1-42 mouse models of cerebral amyloidosis