Background:Stevia’s leaf contains steviol, stevioside and rebaudioside which have
effect to increase secretion insulin. Honey, natural sweetener contains several
antioxidant such as propolis, flavonoid and vitamin. It will eliminate free radicals
and indirectly improve pankreas glands cells to produce insulin. This research was
aimed to know the difference effect of stevia’s ethanol extract comparedto honey on
changing of blood glucoselevel on diabetic model Wistar rats.
Methods:This was experimental research with pre and post test controlled group
design. Samples were 32 male rats, Wistar Strain, 6-8 weeks and + 200 gweight.
Sampling technique used in this research was incidental sampling. Samples were
divided into 4 groups: negative control group (aquadest), positive control
(glibenclamide dose 0.09 mg/200 g body weight), treatment group 1 (stevia’s
ethanol extract dose 20 mg/200 g body weight), treatment group 2 (honey dose 2
ml/200 g body weight). Data were analyze using Saphiro-Wilk’s test of normality
and Friedmann test (α = 0.05) and Post Hoc Multiple Comparison (Wilcoxon) (α =
0.05) using SPSS 17 for Windows.
Results:There was a significant difference (p = 0.002) on the Wistar’s blood
glucose level which was given stevia’s ethanol extract or honey. Stevia’s ethanol
extract effect more on decreasing the blood glucose than honey. But, the both of
them are able to decrease the Wistar’s blood glucose on diabetic model
Conclusions:Stevia’s ethanol extract has the effect of decreasing blood glucose
level on diabetic model Wistar rats better than honey
