S Mac Neil

Both soluble and particulate forms of human platelet guanylate cyclase were found to be sensitive to sub-micromolar concentrations of free Ca2+; soluble enzyme activity increased as Ca2+ was increased from 10 nM to 1 microM; particulate enzyme activity showed a biphasic response to Ca2+, with maximal enzyme activity between 1 and 10 nM free Ca2+ and inhibition occurring at higher Ca2+ concentrations. Neither Ca2+-sensitivity appeared to be calmodulin-dependent.</jats:p

Crossref

Biochemical Journal

Investigation of the role of Ca2+ and calmodulin in the regulation of platelet guanylate cyclase activity

http://www.biochemj.org/content/ppbiochemj/242/2/607.full.pdf

Investigation of the role of Ca2+ and calmodulin in the regulation of platelet guanylate cyclase activity

Abstract

Similar works

Full text

Available Versions

Crossref