Translating noisy sensory signals to perceptual decisions is critical for successful interactions in complex environments. Learning is known to improve perceptual judgments by filtering external noise and task-irrelevant information. Yet, little is known about the brain mechanisms that mediate learning-dependent suppression. Here, we employ ultra-high field magnetic resonance spectroscopy of GABA to test whether suppressive processing in decision-related and visual areas facilitates perceptual judgments during training. We demonstrate that parietal GABA relates to suppression of task-irrelevant information, while learning-dependent changes in visual GABA relate to enhanced performance in target detection and feature discrimination tasks. Combining GABA measurements with functional brain connectivity demonstrates that training on a target detection task involves local connectivity and disinhibition of visual cortex, while training on a feature discrimination task involves inter-cortical interactions that relate to suppressive visual processing. Our findings provide evidence that learning optimizes perceptual decisions through suppressive interactions in decision-related networks.This work was supported by
717 funding to ZK from the Alan Turing Institute, the Biotechnology and Biological Sciences
718 Research Council (Grants: H012508, P021255), the European Community’s Seventh
719 Framework Programme (Grant FP7/ 2007–2013 under agreement PITN-GA 2011-290011),
720 and the Wellcome Trust (Grant 205067). CJS holds a Sir Henry Dale Fellowship, funded by
721 the Wellcome Trust and the Royal Society (102584/Z/13/Z). ELH is supported by the NIHR
722 Oxford Health Biomedical Research Centre. The Wellcome Centre for Integrative
723 Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z)