Background and Objectives: Laparoscopic liver resection for lesions adjacent to major vasculature can be challenging, and many would consider it a contraindication. Recently, however, laparoscopic liver surgeons have been pushing boundaries and approached some of these lesions laparoscopically. We assessed feasibility, safety and oncological efficiency of this laparoscopic approach for these lesions. Methods: This is a monocenter study (2003–2013) describing technique and outcomes of laparoscopic liver resection for lesions adjacent to major vasculature: II occurred in two cases (5 %), with no mortality. Lesions a