Multiple testing with persistent homology

Abstract

Multiple hypothesis testing requires a control procedure. Simply increasing simulations or permutations to meet a Bonferroni-style threshold is prohibitively expensive. In this paper we propose a null model based approach to testing for acyclicity, coupled with a Family-Wise Error Rate (FWER) control method that does not suffer from these computational costs. We adapt an False Discovery Rate (FDR) control approach to the topological setting, and show it to be compatible both with our null model approach and with previous approaches to hypothesis testing in persistent homology. By extending a limit theorem for persistent homology on samples from point processes, we provide theoretical validation for our FWER and FDR control methods