Harbrecht, U

Heun, Reinhard

Klockgether, T

Kolsch, H

Linnebank, A

Linnebank, M

Montenarh, M

Pohl, C

Schnez, K

Schweichel, D

Urbach, H

Wullner, U

Hyperhomocysteinemia is a risk factor for ischemic stroke. We investigated five functional polymorphisms involved in homocysteine metabolism in each 159 stroke patients and controls. The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C &gt; T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C &gt; T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043). This study suggests that the investigated polymorphisms are no major risk factors for stroke, although MTHFR c. 677 C &gt; T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies

University of Birmingham Research Portal

Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study

Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study

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University of Birmingham Research Portal

University of Birmingham Research Portal