Bibliography: leaves 152-194.xxi, 194 leaves : ill. (some col.) ; 30 cm.This thesis has contributed to the knowledge of how the bacteriokine-cytokine network operates by demonstrating how two major proinflammatory mediators interact in modulating the inflammatory response. Furthermore the discovery of CD14 expression on endothelial cells not only provides greater insight in the pathogenesis of bacterial infection, sepsis and perhaps atherosclerosis, it is also likely to influence the future development of new treatment strategies for those conditions.Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 200