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Time to abandon dogma: CD14 is expressed by non-myeloid lineage cells
Authors
Beekhuizen H
Bosco MC
+18 more
Cox GW
Dai L
Fadok VA
Ferrero E
Golenbock DT
Haziot A
Haziot A
Heidenreich S
Hoshino K
Hubertus PA Jersmann
Jayaram Y
Kirkland TN
Li XH
Nishikawa K
Song PI
Vasselon T
Wooten RM
Ziegler‐Heitbrock HW
Publication date
1 January 2005
Publisher
'Wiley'
Doi
Cite
Abstract
© 2007 Australasian Society for ImmunologyCD14 is a pattern recognition receptor; its important role in innate immunity is reviewed here. Since its discovery and subsequent classification at the first leucocyte typing workshop in 1982, CD14 has been thought of as a leucocyte differentiation antigen. However, it has become clear that CD14 is also expressed by many non-myeloid cells, and the evidence for this is presented. The possible role of the presence of low copy number CD14 on non-myeloid cells is discussed. It is time to acknowledge CD14 as an ubiquitous molecule and abandon the position that it is expressed by myeloid cells alone
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Adelaide Research & Scholarship
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