The influence of the blocking of autonomic nerves upon the anaphylactic phenomenon. Part Ⅱ. The influences of the blocking of autonomic nerves by medicines upon the local anaphylactic phenomenon

Abstract

The influences of Ravonal, Procaine, Promethazine and Chlorpromazine upon the local anaphylactic phenomenon on rabbits were investigated. 1. Ravonal anesthesia as well as general and local administration of Procaine have no influences upon the manifestation of the Arthus phenomenon. This is considered to be based on their temporary actions. 2. The general and local administration of Promethazine and Chlorpromazine showed the significant inhibition to the Arthus phenomenon and their effects were shown markedly by the administration of Chlorpromazine. This inhibitory effects are considered to be based on the antagonistic actions against the accentuation of vessel permeabilities through the autonomic nerves. 3. The influences of the anesthesia and artificial hibernation upon the aquiring of the anaphylaxy were investigated by the Arthus phenomenon and the precipitin value in blood and there were no significant differences against the control. This is considered to be based on the incomplete blocking of autonomic nervous function through over the antibody producing periods. 4. Ravonal anesthesia as well as general and local administration of Procaine showed a slight inhibition to the Shwartzman phenomenon. This is, also, considered to be caused by their temporary action, but the manifestation is much earlier than the Arthus phenomenon. 5. The general and local administration of Promethazine or Chlorpromazine showed significant inhibition to the Shwartzman phenomenon. This is considered to be based on the antagonistic action against the accentuation of vessel permeability through the antonomic nerves