We propose a precise tissue characterization method of coronary plaque by using fractal analysis-based features
which are obtained from radiofrequency (RF) signal employing intravascular ultrasound (IVUS) method. The IVUS method is used for the diagnosis of the acute coronary syndromes (ACS). In the proposed method, the fact that the RF signal reflects the complexity of the structure of tissue is used. The effectiveness of the proposed method is verified through a series of experiments by using IVUS RF signals obtained from a rabbit and a human patient