Figure S4. Copy number effect on mRNA and protein abundance on chromosome arm 17q. a) GRB2, LASP1, KPNB1 and ARHGDIA showed significant CNA-protein correlations (pâ<â0.05). The colors depict the range from low (white) to high (green) of copy-number, protein and mRNA abundance. Samples were ranked by copy number at each gene locus. b) ARHGDIA protein was found to be significantly overexpressed in group 4 tumors which frequently harbor 17q gains but not at the mRNA transcript level. Differences among the four subgroups were evaluated based on the Kruskal-Wallisrank-sum test. (PDF 916 kb
