Zebrafish (Danio rerio) as a model for regeneration of organs and tissue

Abstract

Regeneracija je proces u kojem se nadomještaju strukture koje su oštećene ili izgubljene, reaktivacijom razvoja u postembrionalnom dijelu života. Ograničeni regenerativni kapacitet kod ljudi potaknuo je veliku želju za razumijevanjem mehanizama regeneracije korištenjem model organizama. Jedan od najvažnijih model za regeneraciju je zebrica (Danio rerio). Ona je mala tropska riba podrijeklom iz Azije, cijenjena kao model zbog svog lakog uzgoja i sličnosti organa sa sisavcima. Regeneracija organa zebrice uvijek započinje upalom. U regeneraciji repne peraje, srca, mozga i leđne moždine sudjeluju brojne stanice poput kardiomiocita, glija stanica, epidermalmih stanica i signalni putevi poput Notch signala, BMP signala, Fgf signala. Potpunim razumijevanjem staničnih i molekularnih mehanizima regeneracije organa zebrice moguće je otkriće terapeutske metode za popravka oštećenih organa kod ljudi.Regeneration is process in which structures that are damaged or lost are replaced by reactivating development at postembryonic part of life. Limited regenerative capacity in humans has stimulated a great desire to understand regeneration mechanisms by using model organisms. One of the most important regeneration model is zebrafish (Danio rerio). It is a small tropical fish originating from Asia, valued as a model for its easy bredding and similar structure of organs with mammals. Regeneration of zebrafish organs always starts with inflammation. Numerous cells, such as cardiomyocytes, glia cells, epidermal cells are involved in regeneration of caudal fin, heart, brain and spinal cord. Also in regeneration of this organs are involved signal pathways such as Notch signal, BMP signal, Fgf signal. Complete understanding of cellular and molecular mechanisms involved in zebrafish organs regeneration allows discover of therapeutic methods for repairing damaged organs in humans