University of Zagreb. Faculty of Science. Department of Biology.
Abstract
Iako regeneracija i karcinogeneza izgledaju kao potpuno suprotni procesi, zapravo dijele niz sličnosti na molekularnoj i staničnoj razini. Istraživanja ta dva procesa daju kontradiktorne rezultate koji se mogu svesti na dvije suprotne hipoteze. Jedna hipoteza je da pogreške tijekom regeneracije dovode do pojave tumora, a druga da regeneracija zapravo štiti tkivo od pojave tumora. U ovome radu su opisane četiri, do sada otkrivene, veze između regeneracije i karcinoma; tumor supresorski proteini, molekularni signalni putevi, matične stanice te kolektivna migracija. Te poveznice su u radu opisane pojedinačno, ali je bitno naglasiti da su zapravo isprepletene i da međusobno djeluju jedna na drugu. Iz svega navedenog u ovom radu vidljiva je veze regeneracije i karcinogeneze, ali za precizniji opis odnosa između ta dva procesa potrebna su daljnja istraživanja.Although regeneration and carcinogenesis appear to be completely opposite processes, they share a series of similarities at the molecular and cellular level. The research of these two processes gives contradictory results that can be reduced to two opposite hypotheses. One hypothesis is that errors during regeneration lead to the appearance of the tumor and the other that regeneration actually protects the tissue from the appearance of the tumor. This paper describes the four previously discovered links between regeneration and cancer; tumor suppressor proteins, molecular signal pathways, stem cells, and collective migration. It is important to emphasize that these links are interconnected and that they all interact with each other. From this paper, it can be concluded that links between regeneration and carcinogenesis certainly exists on the molecular and cellular level. A more precise definition of the relationship between those two processes requires more research
