The aim of this study was to evaluate the timing of onset and the duration of
action of a single oral-dose treatment with montelukast in comparison to placebo
on exercise-induced asthma (EIA) in asthmatic children. Nineteen children (7-13
years) with stable asthma were evaluated. Patients undertook three consecutive
treadmill exercise tests, respectively, 2, 12 and 24 h after a single-dose
administration. A double-blind randomized, single-dose, placebo-controlled,
crossover design was used. To assess bronchoconstriction after the exercise
challenge, the maximal percentage fall in FEV1 (DeltaFEV1) from the baseline
value was considered. Two hours after dosing, DeltaFEV1 was -15.33 +/- 2.93 for
placebo and -13.33 +/- 2.03 for montelukast. At 12 h, DeltaFEV1 was -18.69 +/-
2.83 for placebo, -9.78 +/- 1.85 for montelukast (p < 0.005). No difference was
observed between placebo (DeltaFEV1-10.21 +/- 2.07) and montelukast
(DeltaFEV1-9.10 +/- 2.02) at 24 h. Analysis of the degree of protection showed a
significant efficacy of montelukast (p = 0.02) in comparison with placebo only at
12 h. Montelukast showed a significant protective effect 12 h after dosing, but
no effect after 2 and 24 h. In mild asthmatics, the timing of administration of
single dosage before exercise should be strictly considered in order to obtain
the drug protective effects