Effect of folic acid and zinc sulphate on endocrine
parameters and seminal antioxidant level after
varicocelectomy
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Abstract
Varicocele is among the most common problems which may lead to male
infertility. Spermatogenesis is impaired as a consequence of this vascular defect,
through mechanisms that are not well described. This study aimed to evaluate
serum hormonal level (inhibin B, FSH and testosterone) and seminal plasma
antioxidant defence levels after folic acid and zinc sulphate administration in
varicocelectomised patients. Participants were randomly allocated to four
experimental groups. Our randomisation schedule was as follows: zinc sulphate/
folic acid, folic acid, zinc sulphate and placebo. The patients underwent
varicocelectomy, before which a blood and semen sample were obtained and
also three and six months after varicocelectomy for evaluation of blood hormonal
level (FSH, testosterone, inhibin B) and seminal oxidative stress status
(nitric oxide, superoxide dismutase, total antioxidant capacity). Patients in different
groups took orally one capsule per day after dinner following varicocelectomy
for 6 months. A significant rise in peripheral blood inhibin B and
seminal plasma activity was detected in the zinc sulphate/folic acid group after
6 months. The present clinical trial indicates a change in the hormonal status
of varicocelectomised patients following long-term administration of zinc
sulphate and folic acid