Assessment of the Effects of Different Sound Pressure Levels on
Distortion Product Otoacoustic Emissions (DPOAEs) in Rats
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Abstract
Excessive exposure to noise can lead to Noise-Induced Hearing Loss. Otoacoustic emissions affect the
microscopic biomechanical activities of healthy outer hair cells. The present study aimed at assessing the
influence of various sound pressure levels on Distortion Product Otoacoustic Emissions (DPOAEs) in rats. To
this end, 27 adult male rats with an age range of 3 to 4 months and a weight of 200 ± 50 g were randomly
divided into nine groups of three. Three groups were considered as the control groups and the rest (i.e. Six
groups) as the case groups. Rats of the case groups were exposed to sound pressure levels of 85, 95, and 105
dBA. White noise was used as the noise to which the rats were exposed. The signal to noise ratio (SNR) of
otoacoustic emissions of rats’ ears was measured at different frequencies in an acoustic room using a DPOAE
machine (4000 I/O manufactured by Homoth of Germany). The collected data were analyzed by the use of
Statistical Package for Social Sciences (SPSS) version 18. The results of SNR measurement indicated that
over 90% of the data had SNR values of 6dB or more. Furthermore, sound pressure level had a significant
negative correlation with SNR, i.e. as the sound pressure level increased, the SNR declined (p<0.001). There
was also a significant negative correlation between exposure time and SNR, meaning that increase in the
exposure time led to decline in the SNR (p=0.008). It is thus concluded that higher sound pressure levels result
in decrease in DPOAE levels