In this article, some of the main contributions to BI (Bio-Impedance) parameter-based systems for medical, biological and
industrial fields, oriented to develop micro laboratory systems are summarized. These small systems are enabled by the development
of new measurement techniques and systems (labs), based on the impedance as biomarker. The electrical properties of the life mater
allow the straightforward, low cost and usually non-invasive measurement methods to define its status or value, with the possibility
to know its time evolution. This work proposes a review of bio-impedance based methods being employed to develop new LoC
(Lab-on-a-Chips) systems, and some open problems identified as main research challenges, such as, the accuracy limits of
measurements techniques, the role of the microelectrode-biological impedance modeling in measurements and system portability
specifications demanded for many applications.Spanish founded Project: TEC 2013-46242-C3-1-P: Integrated Microsystem for Cell Culture AssaysFEDE
