Klinische Nachuntersuchung magnetretinierter Hybridprothesen

Abstract

Many molecules are each other’s mirror images, this phenomenon is called chirality. The separation of such mirror image forms is highly important for the pharmaceutical and fine chemical industries. A good example of this is the scandal surrounding Thalidomide, in which one mirror image (enantiomer) was indeed the effective medicine whereas the other was responsible for the mutilating side effects. Enantioselective liquid-liquid extraction (ELLE) is an upcoming technique for the separation of enantiomers from their respective 1:1 mixture (racemate). Herein, the presence of 2 immiscible liquids and a chiral host is of great importance. The research described in this thesis contains enantiomeric separation of amino alcohols and amino acids applying a variety of chiral phosphoric acids as hosts. Next to the synthesis of these chiral phosphoric acids and a range of derivatives, several scale-up techniques were applied to indicate the industrial validity of the methodology. In the last chapters a new method for the synthesis of carbon-carbon bonds is described. This methodology is of high importance for the synthesis of intermediates for the fine chemical industry