BMJ PUBLISHING GROUP, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
Abstract
Background: Heart pathology in systemic lupus erythematosus (SLE) refers to
the most common manifestations of the disease and largely determines its prognosis..1
2 The pathogenetic constructions of myocardium, endocardium and coronary
vessel lesions remain insufficiently studied..3 4 Histological evaluation of
separate cardiac structures is performed on native models of SLE in linear mice.
Objectives: to study in the experiment on animals (rats) with SLE model the
degree of cardiomyocytes, myocardium, endocardium, valves and cardiac vessel
damage, comparing the results with thymus and spleen tissues histological data.
Methods: The SLE modelling was performed in 53 white non-breeding rats (34
females and 19 males) using full Freund’s adjuvant, splenic deoxyribonucleic acid
of cattle, cyclophosphamide, azid and sodium deoxyribonucleate. Cadmium sulfate,
lithium oxybutyrate and ammonium molybdate were added for feeding animals.
Histological heart specimen were stained with hematoxylin and eosin,
altsyon blue (pH=2.6), van Gieson. PAS-reaction was applied
