Pengaruh Vitamin C terhadap Perbaikan Spermatogenesis dan
Kualitas Spermatozoa Mencit (Mus musculus L.) Setelah Pemberian
Ekstrak Tembakau (Nicotiana tabacum L.)
The aim of this research was to describe the ability of vitamin C in improving the spermatogenesis and
spermatozoa quality of mice after the treatment of tobacco (Nicotiana tabacum L.) extract. The framework of the
research was that it was already known that vitamin C was one of the anti-oxidant, which was able to counter free radical
of the nicotine obtained in tobacco extract in improving the spermatogenesis. The research would be conducted by
grouping the mice into 6 groups, and each group consists of 4 repetitions in 35 days. The first group was as control, the
second group was treated with C vitamin in the dosage of 0.024 mg/g of body weight, the third group was treated with
tobacco extract in the dosage of 0,121 mg/g of body weight, the fourth group was treated with tobacco extract in the
dosage of 0,121 mg/g of body weight and C vitamin of 0,012 mg/g of body weight, the fifth group was treated with
tobacco extract in the dosage of 0,121 mg/g of body weight and C vitamin of 0,024 mg/g of body weight, and the sixth
group was treated with tobacco extract in the dosage of 0,121 mg/g of body weight and C vitamin of 0,036 mg/g of body
weight. Based on the data analysis, it can be concluded that tobacco extract treatment could decrease spermatogenesis
quality and spermatozoa quality of mice (Mus musculus L.). C Vitamin could improve spermatogenesis and spermatozoa
quality of mice after tobacco extract treatment. The optimal dosage of C vitamin treatment to improve the sperma-togenesis and the quality of spermatozoa after the addition of tobacco extract treatment was 0,024 mg/g of weight.
Keywords: vitamin C, tobacco extract, spermatogenesis, spermatozoa