Kadar Glukosa dan Kolesterol Total Darah Tikus Putih (Rattus
norvegicus L.) Hiperglikemik setelah Pemberian Ekstrak Metanol
Akar Meniran (Phyllanthus niruri L.)
The aims of this research were to study the effect of methanol meniran (Phyllanthus niruri L.) root extract
given to the blood glucose and total cholesterol content, and which level of concentration giving significant effect alloxan
treatment. Meniran root contain ellagic acid as antioxidant which provide hypoglicemic capability to reduce diabetic blood
glucose. This research was done by using completely randomized design (CRD) including eight treatments as follow:
negative control (CMC 1%, 2 mL/200 g bw), positive control (glibenclamide 0,126 mg/200 g bw), normal control,
meniran root extract in various concentration (2; 4; 6; 8; 10 mg/200 g bw). Data were elucidated until 15 day of
treatment and analyzed using ANOVA followed by DMRT at 5% confidence level. The result indicated that meniran root
extract giving significant effect on the reduction of blood glucose, however it does not appear to have the same result to
total cholesterol content. At various concentration of meniran root extract, the total cholesterol of rat remain stable. The
optimum concentration to provide hypoglicemic activity raised at 10 mg/200 b bw dose.
Key words: Phyllanthus niruri L., root extract meniran, blood glucose, total cholesterol content
