Synthesis based on cyclohexadienes: Part 4. Novel synthesis of the 6-aryl-2,4-dimethoxybenzoates. Alternariol and methyl trimethylaltenusin

Abstract

A novel method for the preparation of 6-aryl-2,4-dimethoxybenzoic acids involving the Alder–Rickert reaction of 1,5-dimethoxycyclohexa-1,4-dienes and arylpropiolic esters is described. This strategy has been extended to the synthesis of the mould metabolite alternariol and methyl trimethylaltenusin