Binding of Gold(III) with DNA

Abstract

Metal $ions^{1..10}$ are known to bind to DNA. A number of metal ions have been studied and their binding established. $Cu(II)^{8,9,10}$ and $Ag(I)^4$ have been widely studied and ample literature exists on these two metals. On the other hand, the interaction of DNA with gold(III) (which does not occur as $Au^{3+}$ in solution, but rather exists in square planar $complexes^{11}$) has seldom been considered. During the course of our work on this phenomenon Gibson and $co-workers^{12}$ have published a paper recently reporting the results on binding of gold(III) with adenine nucleotides