Overall, 70–85% of individuals will present with chronic low back pain (CLBP). Concepts for its management are multimodal and multidisciplinary. If conservative management fails, surgery becomes an option. Spinal stabilization with fusion is considered a valid option for treating CLBP refractory to conservative management. Efforts have been made to make spinal fusion more efficient as well as more accurate. In a dedicated operating room equipped with intraoperative 3D fluoroscopy and an advanced navigation system, we have demonstrated that these new technologies can help to improve pedicle screw placement during spinal fusion procedures while decreasing the drawbacks associated with imaging utilization. For the first time in humans, we have also safely and efficiently applied osteodifferentiated adipose mesenchymal stem cells to spinal fusion as a graft material. Extended studies are ongoing to confirm our findings(MED - Sciences médicales) -- UCL, 201