CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
research
HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons
Authors
A Mishra
A Schneider
+60 more
AR Amin
B Christensen
B Christensen
BA Kerr
C Gabay
C Hsu
C Molnar
Cristoforo Scavone
DL Butler
DW Gilroy
DW Gilroy
E Anitua
E Homsi
F Cilli
Freddie H. Fu
G Yang
H El-Sharkawy
Hee-Jeong Im
J Damm
J Zhang
J Zhang
J Zhang
J Zhang
James H-C. Wang
JC Peerbooms
JC Peerbooms
JH Wang
JH Wang
Jianying Zhang
K Takai
Kellie K. Middleton
KM Khan
L Engebretsen
LC Almekinders
M Giannopoulou
M Okada
M Tsuzaki
MH Khan
MM Murray
MM Murray
MM Wolfe
P Bendinelli
P Renstrom
R Gong
RE Marx
RJ de Vos
S Fiorucci
S Nakamura
S Narumiya
SH Ferreira
ST Ferry
T Kaido
T Molloy
TE Foster
TJ Williams
U Sheth
UC Kopp
WL Smith
YH Kang
Z Li
Publication date
28 June 2013
Publisher
'Public Library of Science (PLoS)'
Doi
Cite
Abstract
Platelet-rich plasma (PRP) containing hepatocyte growth factor (HGF) and other growth factors are widely used in orthopaedic/sports medicine to repair injured tendons. While PRP treatment is reported to decrease pain in patients with tendon injury, the mechanism of this effect is not clear. Tendon pain is often associated with tendon inflammation, and HGF is known to protect tissues from inflammatory damages. Therefore, we hypothesized that HGF in PRP causes the anti-inflammatory effects. To test this hypothesis, we performed in vitro experiments on rabbit tendon cells and in vivo experiments on a mouse Achilles tendon injury model. We found that addition of PRP or HGF decreased gene expression of COX-1, COX-2, and mPGES-1, induced by the treatment of tendon cells in vitro with IL-1β. Further, the treatment of tendon cell cultures with HGF antibodies reduced the suppressive effects of PRP or HGF on IL-1β-induced COX-1, COX-2, and mPGES-1 gene expressions. Treatment with PRP or HGF almost completely blocked the cellular production of PGE2 and the expression of COX proteins. Finally, injection of PRP or HGF into wounded mouse Achilles tendons in vivo decreased PGE2 production in the tendinous tissues. Injection of platelet-poor plasma (PPP) however, did not reduce PGE2 levels in the wounded tendons, but the injection of HGF antibody inhibited the effects of PRP and HGF. Further, injection of PRP or HGF also decreased COX-1 and COX-2 proteins. These results indicate that PRP exerts anti-inflammatory effects on injured tendons through HGF. This study provides basic scientific evidence to support the use of PRP to treat injured tendons because PRP can reduce inflammation and thereby reduce the associated pain caused by high levels of PGE2. © 2013 Zhang et al
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Crossref
See this paper in CORE
Go to the repository landing page
Download from data provider
info:doi/10.1371%2Fjournal.pon...
Last time updated on 05/06/2019
Public Library of Science (PLOS)
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 05/06/2019
Public Library of Science (PLOS)
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 18/09/2018
D-Scholarship@Pitt
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:d-scholarship.pitt.edu:192...
Last time updated on 19/07/2013
Name not available
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:d-scholarship.pitt.edu:192...
Last time updated on 23/11/2016