Bombicz, Mariann

Gesztelyi, Rudolf

Gálné Remenyik, Judit

Juhász, Béla

Kemény-Beke, Ádám

Kurucz, Andrea

Lampé, Nóra

Priksz, Dániel

Pósa, Anikó

Szabó, Adrienn Mónika

Szabó, Renáta

Varga, Balázs

Molecules

DEA University of Debrecen Electronic Archive

Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat

Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats. Our results prove that the SCSE has a retinoprotective effect in diabetic rats: according to ERG measurements, SCSE treatment mitigated the retinal function-damaging effect of diabetes, and proved to be protective in the diabetic eye against ischemia-reperfusion injuries of the retina. Outcomes suggest that the protective effects of SCSE may occur through several pathways, including HO-1 dependent mechanisms. The observation that SCSE treatment decreases blood glucose is also novel. These findings offer the possibility for development of novel therapeutic strategies utilizing this emerging functional food, in particular in the prevention of conditions resulting from high blood glucose or I/R injury, such as deterioration of retinal microcirculation

Balázs Varga

Dániel Priksz

Nóra Lampé

Mariann Bombicz

Andrea Kurucz

Adrienn Mónika Szabó

Anikó Pósa

Renáta Szabó

Ádám Kemény-Beke

Judit Remenyik

Rudolf Gesztelyi

Béla Juhász

Directory of Open Access Journals

Adrienn Szabó

Crossref

Varga Balázs

Priksz Dániel

Lampé Nóra

Bombicz Mariann

Kurucz Andrea

Szabó Adrienn Mónika

Pósa Anikó

Szabó Renáta

Kemény-Beke Ádám

Gálné Remenyik Judit

Gesztelyi Rudolf

Juhász Béla

SZTE Publicatio Repozitórium - SZTE - Repository of Publications

Multidisciplinary Digital Publishing Institute

http://publicatio.bibl.u-szeged.hu/16308/1/molecules-22-01782.pdf

Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat

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DEA University of Debrecen Electronic Archive

Directory of Open Access Journals

Crossref

SZTE Publicatio Repozitórium - SZTE - Repository of Publications

Multidisciplinary Digital Publishing Institute