The effect of Eck and reverse Eck fistula in dogs with experimental diabetes mellitus

Abstract

1. 1. Dogs with alloxan diabetes were subjected to Eck fistula. This procedure produced a marked increase in the amount of insulin necessary to control glycosuria. When the dogs were fasted, glycosuria disappeared, blood sugars fell toward normal, and the need for insulin was eliminated. 2. 2. Reverse Eck fistula was created in dogs with alloxan diabetes, and resulted in minor increases of doubtful significance in daily insulin requirement. When fasted, the blood sugar of these animals remained elevated and glycosuria continued. 3. 3. Nondiabetic dogs with Eck fistula all died of meat intoxication. Dogs with Eck fistula plus diabetes had no evidence of meat intoxication and in general were in better health than dogs with Eck fistula alone. 4. 4. Possible mechanisms of the role of Eck fistula in the alteration of the diabetic state are discussed. © 1959