Faris, TD

Herrmann, TJ

Marchioro, TL

Starzl, TE

Taylor, PD

D-Scholarship@Pitt

L A T E  FUSCTIOS OF THE ORTHOTOPIC LIVER HOJIOGR.4FT TASOL-s D. FARIS, N.D., THOMAS L. ~IARCHIORO. I\I.D., F.A.C.S., THO;\~AS J. HERRMASS, 1f.D.. PAUL D. TAYLOR, AND THOMAS E. TARZL, N.D., F.A.C.S. THE CLINICAL and histologic features of the liver homografts of long term dog sur\.ivors following orthotopic hepatic homotransl>lantation have recently been described (1). T h e  liver function of 9 oI these ani- mals \+.as studied 98 to 442 days after operation. In  each case immuno- suppressive therapy was discontinued from 110 to 131 days after transplantation. In 1 (SS-4), subsequent deterioration of h o m v a f t  function occurred necessitating resumption of azathioprine. RESULTS T h e  results of standard liver function tests are shown in Table I. One  animal (S3j-4) was completely normal; the other 8 showed \-ar?- ing degrees of hepatic dysfunction. A 5 hr. glucose tolerance test was normal in 5 of 6 dogs. Normal hyperglycemic response to 100 g. of intravenous glucagon was present in 5 of 7 animals tested, while a minimal glycogenolytic response appeared in 2 (SS-4; Sch-9). I n  5 dops with good liver function, plasma cholesterol, phospholipids, and triglycerides were normal both on a regular kennel diet and a 117 gm. per day fat diet. I n  general the hepatic functional derangements paralleled the microscopic abnormalities previously described (1). T h e  causes of the 4 deaths were liver failure (ICRhl-13; SS-4). liver failure and a bleed- ing duodenal ulcer (1-10). and perforated duodenal ulcer (S3"lS). The clinical condition of the survivors corresponds to their liver func- tion. This  long term retention of life-sustaining liver function after hepatic homotransplantation is distinctly encouraging. REFERESCE 1. ST-~RZL, T. E., \ ~ . ~ R C H I O R O .  T. L.. PORTER, );. A,,  TAYLOR, P. D.. F4~15. T. D., HERRJIANX, T. J . ,  H L ~ D ,  C. J . ,  and \ V . ~ D D E L L ,  It'. R. Factors determining short and lotig term survi\.al after orthotopic liver homotransplantation in the dog. Surger!, Jul!. 1965 (in press). Fro111 tile Department of Surge?, the C'niversity of Colorado School of ,!ft-dihnc and the  Denr'er I'eterans Ad~ninistration Hospital, Denver. Aided by U .  S. Publrr H r a l t l ~  Senlice Grants A.V-06283, AM-06344, HE-07735, AM-01712, and AIWIS2.  Reprint from Vol. XVI, Surgical Foruril, American College of Surg-ons. 1x5 Tfibtc 1-1,ivcr 1;lrticl ion Tcst.~ LAST DETER~~INATION (.ATE ~ET~R~~~NATION** -_ - -- - 4 4: 6 - 2 I .. 4 I- z *. A : i VI - - 0" YQ 2 t C .a z; am -I t o E w g$ FE I 2" 9 . > 4 - 2 Z: 5 m 2y $2 g !5 1 % '2 - - 3 -I % ,. z = =, -1 2 5 8 74 z 2 / /I : 2 2: < I- -I C: L 3 m I- 2 F '* 2 s- 4: i i < d2 & s ? 2 4 d g n 2 o % c < - 8.0 7.3 6.74 2.64 0.64 24 34 2.1 S:!5-l 4:lti - -. .. . . -_ __L 0.1 . .- . . . -- ..- 50 33.6 1 G.0 6.5 7.12 1.67 0.3 I *S.75-I8 332 0.1 28 -- .. _.-- . . . . . . .. . . . .~.. . - . ~ . 1 no 9.5 8.0 7 .So 2.88 0.65 -111-lhf-2 330 ~ 0.2 70 2 1 . .-._ , .. .-- - - - . . -. . - in0 11.5 7 .ti 6.96 3.10 0.PO -. :!?? 0.0 3:) 7.3 llilil-I? -. - -- -__.__-- --- _ - 380 10.1 7 .O 5.18 2.32 0.8 l 237 4.0 555 114 *SS-4 -- _ ---.- -- ~- -. - . -. - - .. - . . .___- 5 5 G .:5 2.36 0:lR 202 77 265 21 - -- S:F-27 0.2 - - 7.30 . ._ .- -. . - -. . -. - . . . -. . . _-- -- 412 43.0 11.0 (i.38 1.88 0.42 3.7 100 9GO -. --. - Sell-9 I !)3 -_ -. _ -- 110 179.5 4.83 7.9.- 0.57 0.13 *I-I0 I 63 4.7 62 ---- 485 65.0 13.7 6.03 -- *lCl\hl-13 153 4 .8 280 64 - <:on~rols (I?) 14- 0.7- 3.5- 9 .O 3- 6.0- 5.47- 2.44- 0.70- I<;lngc 0.0- 7 .li 6.57 3.72 158 48 71 2.5 -- 0.3 -- 1.5 6.6 6.6 5.93 3.05 1.09 Average 0.1 I8 28 Dcacl *. ~c,rml~n~llill,ls Wrrc ,lone vitllill 51 11ays nf t~ic Inst c~ctcrlninati~~l. crccpt for ss-4. In lllis dog 'he nsP test was ;It 118 cl;lys, nrl(l ~llc. I,lr,rl~rr,~~~l,i~l ti~llr i111c1 prnI~i1ls 15.4 (lays. 

Late function of the orthotopic liver homograft.

Name not available

Late function of the orthotopic liver homograft

http://d-scholarship.pitt.edu/3491/1/31735062123587.pdf

Late function of the orthotopic liver homograft.

Abstract

Similar works

Full text

Available Versions

D-Scholarship@Pitt

Name not available

Name not available