Arbogast, Helmut

Arndt, H.

Daniel, P.

Schulte-Herbrüggen, T.

Sprengard, M.

Szinicz, L.

German

Universität München: Elektronischen Publikationen

EFFECT OF SOMAN, ATROPINE AND PYRIDINIUM,1-(((4-

CARBAMOYL-PYRIDINΙΟ) METHOXY) METHYL)-2-(HYDROXYIMlNOMETHYL)

DICHLORIDE MONOHYDRATE (HI-6)

UPON VARIOUS BEHAVIOURAL PARAMETERS IN MICE.

Open Access LMU

Deutsche Gesellschaft für Pharmakologie und Toxikologie Abstracts Fall Meeting September 19-22, 1988, Hamburg Note to subscribers: This Supplement forms part of the subscription Springer International Deutsche Gesellschaft für Pharmakologie und Toxikologie F a l l Meeting Hamburg, September 19 - 22, 1988 Contents Abstract Numbers RUDOLF-BUCHHEIM-LECTURE 1 SYMPOSIA 1 The Carcinogenic Risk of Chemicals to Humans. The Role of Animal and Human C e l l Culture Studies 2 - 8 2 Phys i o l o g i c a l , Pathophysiological and Therapeutic Aspects of Neurotransmitter Uptake and Release 9 - 14 3 Phosphoinositides and Receptor Function 15 - 20 4 Problems Concerning Thresholds of Non-Genotoxic Carcinogenes 21 - 26 5 New Trends i n Immunopharmacology 27 - 32 6 New Pos i t i v e I n o t r o p i c Agents 33 - 39 7 E n a n t i o s e l e c t i v i t y of Action and Metabolism of C h i r a l Drugs 40 - 45 8 Local Mediators of Vascular Tone 46 - 51 9 El e c t r o p h y s i o l o g i c a l and Pharmacological Properties of Ionic Channels 52 - 57 COMMUNICATIONS 1 Molecular Pharmacology 58 - 61 2 Pharmacokinetics, Transmembrane Transport 62 - 70 3 Drug Metabolism, Biochemical Pharmacology 71 - 75 4 Signal Transduction 76 - 86 5 Renal Pharmacology 87 - 89 6 Calcium Entry Blockers 90 - 98 7 Heart 99 - 144 8 Smooth Muscle 145 - 149 9 C i r c u l a t i o n 150 - 157 10 G a s t r o i n t e s t i n a l Tract 158 - 164 11 Endocrine Pharmacology 165 - 169 12 Eicosanoids 170 - 174 13 Immunopharmacology, Inflammation 175 - 183 14 Cholinergic Mechanisms 184 - 195 15 Adrenergic Mechanisms 196 - 211 16 Serotoninergic Mechanisms 212 - 216 17 Central Nervous System 217 - 235 18 Toxicology 236 - 256 19 C l i n i c a l Pharmacology 257 - 289 20 Miscellaneous 290 - 294 IV A U T H O R I N D E X Figures r e f e r to Abstract Numbers Aasen A 193 Brockmeyer D 286 Achterberg V 105 Brockmöller J 241 Achtert G 156 Brodde OE 85 Aissa J 157 Bruchhausen F ν 173 Aktories Κ 145 Brückner R 125 Albus U 70, 114 Brune Κ 266 Alexandriens Τ 269 , 289 Büch U 68 A l l i k m e t s LH 234 Bürde R 76 Alves C 115 Buschmann G 143 Ammon HPT 291 Camus J 192 Anden NE 13 Carlberg R 272 Anders A 256 Carter HR 15 Andrae U 23 Casals-Stenzel J 164 Appel KE 243 , 244 Cereska KZ 234 Arbogast Η Ariens EJ 188 Challiss RAJ 226 40 Chedid L 32 Armah BI 88, 105, 109 Chodera A 229 119, 120, 121 Chodkowska A 232 125, 167, 168 Christ W 222 169, 206, 207 Christophe J 192, 193 Arndt Η 176, 188, 239 Cohnen Ε 88, 206 Arndt JO 253 Cojocel C 89 Assion HJ 288 Colberg Η 108, 128 Augustin C 71 Cole J 7 Bach GL 266 Colquhoun D 52 Bagdy Ε 233 Conrady-Lorck S 251 Batty IH 19 Coutinho Μ 278 Bauch HJ 85 Cuprunov Μ 241, 263 Bauer A 160 Czuczwar SJ 232 Bauer Β 287 Dammann F 189 Baumann Β 189 Daniel PT 176, 188, 239 Baumann Κ 246 Danielsen W 124 Beck Τ 227 Darius Η 47, 171 Beckmann R 216 Daul A 85 Beermann D 270 Dayer JM 29 Behrens C 271 Dedecke R 129 Beinborn Μ 158 Dehn A 62, 153, 157 B e i l W 158 Deinum J 211 Beltman W 195 Dengler HJ 286 Beiz GG 258 , 261 Dennhardt R 264 Benes' L 163 Derwahl Μ 279 Benthe HF 71. , 88 Deutschmann S 248 , 250 Beresewicz A 99 Dhein S 110 Berg I 106 Diamantstein Τ 28 Berg PA 176 Diederen W 117, 131 Berger F 112 Dierdorf D 281 Berghout A 65 Diet F 102, 118 Bersimbaev RI 158 Di e t e r i c h A 278 Bette Ρ 183 D i e t e r i c h HA 259 Betz R 215 D i t t r i c h S 67 Bialas S 98 Djonlagic* Η 257 Bickel U 264 Döring V 103 Bicke l C 275 Donaubauer HH 114 B i r d s a l l NJM 184, 194 Donn F 71 Blaich G 240 Dooley DJ 218 Blaschke G 42 Drakoulis Ν 241 B u e r Ρ 10 Dresbach Κ 95 Bockaert J 78 Drobny Η 219 Böhm Μ 102, 118, 130 Dross Κ 61 Böhme Ε 81, 146 Drube S 177 Bönisch Η 9 Drummond AH 20 Boer R 92( , 96, 184 Eberle G 8 Bognar I 189 Ebner F 127 Boldt J 259 Eckl KM 262, 276, 280 Bolt HM 250 281, 282 Bo l t Μ 250 Eisenbrand G 245 Borchard U 112 Elisovä Κ 209 Borchers F 156 E l l i n g Η 151 Borcholte Τ 224 Eltze Μ 92, 184, 194 Borel JF 27 Elzinga CRS 195 Borsy J 233 Engeholm C 244 Borte1 Μ 231 Engler Η 144 Bo r t e l LM van 277 Enterung D 283 B o u i l l o n Τ 16 Erbel R 278 Braak KJ 149 Erdmann Ε 39, 102, 118 Brasch Η 140, 199 130 Braun W 162 Erdmann G 224 Breithaupt Κ 258 Fain JN 15 Brendler S 237 Farjam A 87 Breyer-Pfaff U 74 Fecht-Kempter I 66 186, 191, 193 213 218 251 98 215, 225 263 113 220 155 46, 198 249 186 251 59, 238 27 258 80, 81 196 276, 280, 281 183 221 93, 94, 134 135, 136 182 1.8 9 270 92 10 114 81 293 80, 81 266 106, 142 146 16 218 222 41, 90, 91 96 Goerke F 165 Görsdorf S 244 Göthert Μ 212, 215, 225 Gold R 285 Goppelt-Stübe Μ 175 Grassegger F 96 Graziadei I 90 Greb WH 262, 276, 280 281, 282 Green Τ 24 Greim Η 23 Greven J 8 7 Grimminger W 154 Grohs JG 113 Groß G 197, 202 Grosser R 91 Grüne S 222 Grundler G 184, 194 Gülker Η 111 Güttier Κ 95 GumuZka SW 235 Guse AH 106 Guthmann F 81 Haas Μ 211 Habberfield AD 60 Habermann Ε 183 Hader S 155 Haen Ε 67 Häringer EP 281 Hafner D 112 H a l l i e r Ε 250 Hamulyäk Κ 268 Han SP 14 Hanft G 197, 202 Hannemann J 2 46 Hansen-Schmidt S 283 Harder S 265, 270 Harris CC 2 Hass R 175 F e i f e i R F e l i x W Feuerstein TJ F i c h t l Β F i l i p e k Β Fink Κ Fink Ρ Fischer G Fischer HD F l e i s s i g W Förstermann U Föst U Forth Β Forth W Foth Η Foxwell BMJ Fraedrich U Frank R Freissmuth Μ Freude J Frevert J Frey HH Fricke U Friedberg KD Fuder Η Fuhr U Galvan Μ Galzin AM Ganten D Gareis R Garza Ocäfias L Gausepohl Η Geisslinger G Gercken G Gerlach J Gierschik Ρ Gilsbach JM Gindler Κ Glossmann Η ν Hausleiter HJ 156 Kinast G 91 Haverkamp W 111 Kiräly I 233 Hecker Ε 22, 292 Ki r s t e n R 260, 269 , 289 Hecker W 222 Klaus W 94, 110, 134 Heger-Mahn D 263 135, 141 Heinzow Β 271 Klauser RJ 151 Heistracher Ρ 138 Kl e i n G 269 , 289 Hellenbrecht D 272 Klein Η 30 Hempelmann G 259 Kl e i n MM 146 Henderson Κ 14 Kle i n R 237 Henn J 245 Kleinrok Ζ 232 Hennighausen G 179 Kiemisch W 66 Herberg L 167, 168 Kliem V 224 Hergenröder S 123 Kl i n g L 132 Hering S 91 Klosa Μ 291 Herman ZS 223 Klostermann Μ 276 Hermans JJR 75 Kmieciak-KoZada Κ 223 , 230 Herrmann F 30 Knaus HG 41, - 91 Herter R 144 Knöll Β 189 Herrlinger C 144 Knot HJ 210 Hescheler J 33 Koch Ρ 208 Heuer Η 164, 180 Köbele W 276 Heuer HO 171 Köhler L 175 Hildebrand Μ 267 Körner C 205 Hildebrandt A 26 Koesling D 81, r 82 H i l f G 16 Kohl C 126 Hindricks G 111 Kohler Μ 142 Hinsch KD 80, 81, r 82 103 Kolb W Kojda G 117 94 Hirzebruch Μ 286 Kokubun S 35 Hodenberg Α ν 66 Kolker HJ 210 Hoedt-Schmidt S 181 Korth Μ 100 Höer D 77 Krec'ek J 163 Höltje HD 41 Kremer HJ 134, 135 Hofferber Ε 121, 207 Kress G 279 Hoffmann Β 256 Kretz FJ 274 , 275 Hoffmann Κ 281 Kreye VAW 51 Hohlfeld J 198 K r i e g l s t e i n J 227 Hollenga C 211 Krumpl G 139 Holzschuh J 176 Krupa Η 201 Honerjäger Ρ 38, 119 Krupinska J 98 Hopff WH 290 Kühl UG 143 Horstmann R 273, 284 Kühnel W 252 Hropot Μ 70 Künster A 187, 190 Huber Τ 260 Künzer Τ 134, 135 Hüller Η 285 Kuhlmann J 273 , 284 Hütter JF 62, 115, 148 Kunz W 25 153, 157 Kurowski V 73 Hufnagel Β 88 Kurz Η 67 Hughes PJ 20 Kuschinsky Κ 227 , 228 Huh Ν 8 Kwiatkowski A 77 Hunter J 64 Lachmann G 156 Hust R 281 Ladwein Ε 187 Huttunen Ρ 161 Laib RJ 248 Huzarska Μ 223 , 230 Langer SZ 10 I l l e s Ρ 49, 217 Lambrecht G 186, 191, 192 Isenberg JC 68 193 Iven Η 73, 257 Lange Ρ 179 Jacobitz Ρ 207 Large ΤΗ 58 Jacobsen Μ 222 Legrum Β 65 Jähnchen Ε 44 L e i t o l d Μ 155 Jakob Η 33 Lembeck F 1 Jakobs KH 16 Lenzen S 79 Janicke I 241 Leyen Η ν der 34, 108, 128 J a n i c k i PK 235 Librowski Τ 98 Janzowski C 245 Liebau S 198 Joels LA 20 Liermann J 270 Johannes A 72 Lindemann A 30 Joost HG 60 Lins S 166 Junge Η 222 Linz W 70, 114 Kaever V 170, 175 L i p f e r t Ρ 253 Kahl GF 59 Lissner R 269, 289 Kahl R 238 Liu Β 101 Kalkbrenner F 173 Locher Μ 160 Kalmar Ρ 103 Loew D 266 Kaschube Μ 140 Looby Μ 63 Kasemann R 247, 249 Lubach D 178 Kaufmann Β 33 Lucking CH 218 Kelemen Κ 116 Lues I 133 Kemkes Β 102 Mackert G 172 Ker l e r F 281 Macherey HJ 159 Kessler Ρ 269, 289 Madie S 242 Kewitz Η 63 Magnussen C 252 Kietzmann Μ 178 Mago-Karäcsony Ε 233 K i l b i n g e r Η 12, 185, 214 Magyar Κ 294 Mahlmann S 86 Maier C 271 Malek U 232 Malerczyk V 287 Malkewitz J 81 Malorny U 177 Mannhold R 61 Marczynski^ Β 249 Marko R 116 Marrer S 41 Marsmann Μ 91 Masslich U 119 Matthes Η 267, 274 Matthews G 54 Mauler F 183 Mauss S 145 Mauz A 131 Mayer D 89 Mayer MER 281 McDermott BJ 107 Meel JCA van 131 Meese CO 43 Meineke I 283 Meinetsberger Ε 151 Mermi J 127 Mensing Η 205 Merode Τ van 277 Mertelsmann R 30 Metz U 85 Metzenauer Ρ 129 Metzler Μ 240 Meuter C 137 Mey C de 283 Meyer J 278 Meyer W 34, 108, 128 Meyerhof W 86 Meyer-Ingold W 105 Meyerinck L ν 71, , 72, 103 Micheal-Hepp J 9 Michel MC 85 M i l l a r BC 107 M i t r o v i c V 260 Möhler Η 53 Möller Μ 282 Mörsdorf Ρ 144 Moiderings GJ 212, 225 Morano I 36 Moser U 191 Moshammer Τ 90 Muacevic G 174 Mühlbachovä Ε 209 Mühlbauer R 276 Mülle A 250 Müller A 110 Müller Β 216 Müller CE 176 Müller L 242 Müller W 89 Müller-Beckmann Β 132 Müller-Schweinitzer Ε 152 Mülsch A 147 Muster D 120 Mutschier Ε 186, 191, 192 193, 261 Naes L 14 Nahorski SR 19 Nanoff C 196 Nau Η 146 Nawrath Η 33 Neher Ε 54 Nehls Ρ 8 Neubert D 6 Neumann HG 21 Neumann J 103, 104 Nicholson CD 226 Niedermayer W 279 N i l l Κ 74 Niroomand F 81 Nixdorf ü 278 N o l l D 245 Nose Μ 205 Nowak Κ 228 Nowakowska Ε 229 Nusser Ε 74 Oberdisse Ε 77 VI Odenthal KP 154 Rosenthal W 80, 82, , 83 Sewing KF 158, 160 Oesch F 3 Rost L 263 Seyberth HW 172 Offermanns S 83 Rudolph Ε 220 Sharma VK 100 Ohno-Shosaku Τ 166 Rudolph U 82 Sheu SS 100 Oppermann S 109 Rüdiger HW 5 Sidiropoulos D 16 Osswald Η 87 Rüegg JC 36 Siess W 18 Oster W 30 Rülander G 280 Sigel Ε 55 Ostertag W 170 Ruiz Larrea F 20 Simonovä J 209 Ottenwälder Η 247 Rumberger Ε 109 Simpson IA 60 Ould G 279 Rump LC 200 Singer EA 204, 219 Paar WD 286 Ruoho AE 60 Sippel Η 254, 255 Pallas S 189 Rupp J 33 S i t z l e r G 136 Palm D 261 Rustenbeck I 79 Sladeczek F 78 P a n i j e l Μ 281 R y f f e l Β 27 Smeets FA 277 Panten U 56, 165, 166 Sanders KH 92 Smith RL 45 Pape S 167, 168 Saxena PR 50 Soboll S 115 Partke HJ 168 Schadewaldt Ρ 84 Sorg C 177 Passow Η 65 Schäcker Μ 238 Spicher Κ 103 Pegram BL 64 Schäfer R 17 Sponer G 132 Peisdersky Β 275 Schäfer SG 251 Sprengard Μ 188 Pelzer D 57 Schäfer-Körting Μ 261 Staib AH 265, 270 Penner R 54 Scheidemandel V 281 Staib W 84 Pentz R 252 Sche i f f e l e R 263 Staks Τ 267 Peter Η 249 Scheper Τ 243 Stampfl A 122 Peters Τ 64, 69, 137 Scherkl R 221 Stangl A 218 208 Scheufler Ε 64, 69 Stapper NJ 84 Petersen KU 159 Schierenberg Μ 171 Starke Κ 11 P f a h l e r t V 144 Schlepper Μ 260 Steigerwald G 213 Pfannkuche HJ 170 Schlicker Ε 215, 225 Stein Β 104 P f i t z e r G 133 Schioos J 261 Steinkraus V 205 Picke D 141 Schmezer Ρ 237 Steinmann U 254 , 255 Pieske Β 130 Schmidt BH 78 Steinwachs MR 59 Pineyro AL 293 Schmidt ES 286 Stenzel W 121 Piper HM 107 Schmidt Η 182 Stock G 216 Pitschner HF 261 Schmidt HHHW 146 Stock KP 266 P i t t n e r t Η 204 Schmidt J 220 Stolzenburg Κ 258 Podehl R 95 Schmidt W 153 S t r a s c h i l l Μ 274 Pöch G 236 Schmied R 100 St r e i n Κ 132 Pool BL 237 Schmitz Η 273 S t r i e s s n i g J 41 / 91 Pooth R 260 Schmitz W 34 , 103, 104 Strohmann C 186, 191, 193 Porzig Η 35 124 , 125, 126 S t r u b e l t 0 252 Potter BVL 19 Schmoldt A 71, 72 Strupish J 19 Prescher KE 146 Schmutzler W 177 Süß KD 12 Prod'hom Β 35 Sehne f e i S 17 Suttorp Ν 183 Prostran Μ 150 Schneider Ε 213 Szinicz L 188, 239 Puurunen J 161 Schneider F 203 Tacke R 186, 191, 192 Raake W 151 Schömig Ε 9 193 Raberger G Racke Κ 113, 139 Schölkens BA 70, 114 Tang Μ 33 201, 214 Schoepke Μ 243 Tastenoy Μ 192 Ramsch KD 284 Schollmeyer Ρ 200 Tötzber S 139 Rafeiner Κ 191 Scholtysik G 37 Teuteffiacher Η 111 Rahn KH 277 Scholz Η 34 , 103, 104 Thevenod Ρ 17 Rajewsky MF 8 108 , 124, 125 Theisohn Μ 288 Raida Μ 65 126, 128 Thijssen HHW 75, 268 Ras'kovä Η 163 Scholz J 126 Thomale J 8 Ravens U 101 Scholz W 70 Thomsen Τ .263 Regenold JT 217 Schräder HW ν 281 T i l s C 274 Reichardt LF 58 Schröder G 216 T i t s Β van 85 Reichl R 123 Schröter Κ 56 Todt Η 139 R e i f f e n s t e i n RJ 236 Schroth Μ 132 T^orres-Alanis 0 293 Reimann W 203 Schudt C 96 , 184, 194 Toth Μ 126 Reinke Μ 172 Schürmann A 60 Traunecker W 123 Remie R 210 Schütz W 196 Traupe Β 125 Remmers C 253 Schulte-Herbrüggen Τ 176, 1β8 Trautwein W 33 Reneman RS 277 239 Trc*ka V 209 Resch Κ 170, 175 Schultz G 76, 80, 82 Treese Ν 278 Reuter Η 35 83 Trenk D 44 Reymann A 162 Schulz BG 216 Trübe G 56, 166 Rhein S 278 Schulz I 17 Trzeciak HI 231 Richter D 86 Schulz Μ 71 Tychowiecka I 80 Rieckmann C 62 Schulze C 265 Ueckert Μ 93 Riedel R 184 Schuster 0 156 Unruh GE ν 286 Rieß G 269, 289 Schwanstecher Μ 165 Urbanovä Ζ 204, 163 Rippmann F 22, 292 Schwarz JR 86 Valenta Β 219 R i t t e r J 241 Schwarz Μ 25 Varagic VM 150 R i t t l e r J 148 Schweer Η 172 Varchmin G 143 Riveau GJ 32 Schwenk Μ 160 Vens-Cappell F 260 Riz i k Κ 14 Schwenner Ε 91 Verspohl EJ 291 Röbke A 252 Schwörer Η 12 , 185, 214 V i e r l i n g W 122 Rosen R 141 Schwulera U 269, 289 Völmle Κ 64 278 Röthig HJ 287 Seeger W 48 Vogelgesang R , 69 Roewer Ν 109 Seib C 77 Voigt Κ 264 R o f f e l AF 195 S e i f e r t R 76 Vollmer KO 66 Rombusch Μ 33 S e i f e r t W 267 Vosdellen G 253 Roots I 241, 263 Sekardi LJ 182 Wadzinsky BE 60 VII Waelbroeck Μ 192, 193 Wallace ΜΑ 15 Wang XL 85, 101 Wankerl Μ 102 Wasilewski Ε 138 Wawrzynczak EJ 31 Weber Η 273, 284 Weber W 63, 263 Weiss S 78 Wellhöner HH 224 Wellst e i n A 261 Welsch-Kunze S 228 Wenke Μ 209 Wenzel J 227 Wenzlaff Η 108, 128 Wermelskirchen D 64 Werner G 94 Werner U 288 Weskamp G 58 Wessel Κ 170 Wessler I 187, 190 West f a l l TC 14 Wettwer Ε 101 Wiebel F 4 Wiedemann Η 111 Wiegand-Löhnert C 264 Wiegand Η 97 Wieland Τ 16 Wienen W 131 Wieser Μ 30 Wietholt D 111 Wilberz S 167 W i l f f e r t Β 64, 208 Wilhelm D 137, 208 Wilke R 226 Willcocks AL 19 Wingender W 284 Winguth Τ 109 W i t t f o h t W 146 Woermann C 162 Wojtowicz Ε 232 Wolf D 281 Wolf Τ 247 Woyzella G 146 Wronski R 279 Wurm G 173 Wustmann C 220 Younes Μ 252 Zaagsma J 195, 210, 211 Zahorsky R 279 Zankl Η 245 Zeeuw RA de 195 Z e l l e r WJ 237 Zernig G 90 Zharkovsky AM 234 Ziegler D 143 Zier G 219 Zünkler J 56 Zünkler BJ 166 Zwadlo-Klarwasser G 177 R60 188 EFFECT OF SOMAN, ATROPINE AND PYRIDINIUM,1-(((4-CARBAMOYL-PYRIDINΙΟ) METHOXY) METHYL)-2-(HYDRO-XYIMlNOMETHYL) DICHLORIDE MONOHYDRATE (HI-6) UPON VARIOUS BEHAVIOURAL PARAMETERS IN MICE. H.Arndt, H.Arbogast, Μ.Sprengard, T.Schulte-Herbrüggen, P.Daniel, L.Szinicz. Disturbed f u n c t i o n of various organs may be cau-sed by compounds i n f l u e n c i n g c h o l i n e r g i c synap-t i c transmission. I n order to study the underly-ing mechanisms, behavioural e f f e c t s of the cho-linomimetic agent soman, an acetylcholinesterase (AChE) i n h i b i t o r , were in v e s t i g a t e d without and a f t e r treatment of mice w i t h the a n t i c h o l i n e r g i c drug atropine and the AChE r e a c t i v a t o r HI-6. Groups of ten mice receiving e i t h e r 0.9% saline s.c. and i . p . , soman s.c. and saline i . p . , or soman s.c. and antidote (s) i . p . , were allowed to run f o r 60 min on a r o t a t i n g mash wire drum (14 rpm, 20 cm diam.) immediately a f t e r treatment. Various behavioural parameters according to I r -win (Psychopharmacol. 1_3 : 222 , 1968) were tested before i n j e c t i o n and a f t e r the running period. I n soman-treated animals a dose dependent de-crease of running performance, behavioural {ac-t i v i t y , r e f l e x e s , v i s u a l p l a c i n g ) , neurologic (muscle tone, tremor) and autonomic parameters ( s a l i v a t i o n , lacrimation) was observed. HI-6 improved running performance and v i s u a l placing only, whereas atropine abolished the e f f e c t of soman upon nearly a l l behavioural, neurologic and autonomic parameters. The data show t h a t most behavioural e f f e c t s of soman, even the muscular ones, are responsive to atropine treatment documenting the muscarinic nature of these parameters. I n s t i t u t für Pharmakologie und Toxikologie der Akademie des Sanitäts- und Gesundheitswesens der Bundeswehr, BSW, Ingolstädter Landstr. 98, D-804 6 Garching-Hochbrück.FRG 

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EFFECT OF SOMAN, ATROPINE AND PYRIDINIUM,1-(((4- CARBAMOYL-PYRIDINΙΟ) METHOXY) METHYL)-2-(HYDROXYIMlNOMETHYL) DICHLORIDE MONOHYDRATE (HI-6) UPON VARIOUS BEHAVIOURAL PARAMETERS IN MICE.

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